The physiological mechanism

The objective of this research was to determine the role of neural feedback and muscle mechanics in the generation of physiological tremor oscillation. This research developed a neuromuscular model to simulate the individual and resulting oscillatory mechanisms of tremor. The oscillations found in EMG signal were also analysed empirically from EMG data from 54 subjects using Hilbert Transform and rectification to obtain the envelope of the signal. The time between rhythmical waveform patterns in the EMG signal, TC was found to be 78ms.

117p runthenight07 01-03-2023 6 3   Download

The objectives of the thesis: Investigate the role of A20 in regulating four physiological functions of DCs including maturation, cytokine secretion, migration and apoptosis. Investigate the effect of A20 on the regulating three molecular signals including NF-κB, STAT1 and STAT3 related to the physiological process of DCs.

27p extraenglish 24-05-2021 13 4   Download

The objectives of the thesis: Investigate the role of A20 in regulating four physiological functions of DCs including maturation, cytokine secretion, migration and apoptosis; investigate the effect of A20 on the regulating three molecular signals including NF-κB, STAT1 and STAT3 related to the physiological process of DCs.

27p capheviahe27 23-02-2021 14 4   Download

Considering accurate constitutive models is of the utmost importance when capturing the mechanical response of soft tissue and biomedical materials under physiological loading conditions. This paper investigated the behaviour of porcine myocardium in passive rested hearts. This was done by applying biaxial loads on the myocardium.

12p tohitohi 19-05-2020 11 0   Download

The signaling properties of the gasotransmitter molecule hydrogen sulfide (H2S), which is endogenously generated in plant cells, are mainly observed during persulfidation, a protein post-translational modification (PTM) that affects redox-sensitive cysteine residues. There is growing experimental evidence that H2S in higher plants may function as a mechanism of response to environmental stress conditions.

7p partimesinhvien 08-05-2020 31 0   Download

The Sir2 family of histone⁄protein deacetylases (sirtuins) is comprised of homologues found across all kingdoms of life. These enzymes catalyse a unique reaction in which NAD + and acetylated substrate are converted into deacetylated product, nicotinamide, and a novel metabolite O-acetyl ADP-ribose. Although the catalytic mechanism is well conserved across Sir2 family members, sirtuins display differential specificity toward acetyl-ated substrates, which translates into an expanding range of physiological functions. ...

10p fptmusic 11-04-2013 42 3   Download

The formation of amyloid fibrils is associated with various human medical disorders of unrelated origin. Recent research indicates that self-assembled amyloid fibrils are also involved in physiological processes in several micro-organisms. Yet, the molecular basis for the recognition and self-assembly processes mediating the formation of such structures from their soluble protein precursors is not fully understood.

8p dell39 27-03-2013 38 5   Download

The family of testis-specific serine–threonine kinases (TSSKs) consists of four members whose expression is confined almost exclusively to testis. Very little is known about their physiological role and mechanisms of action. We cloned human and mouse TSSK3 and analysed the biochemical properties, substrate specificity and in vitro activation.

14p dell39 27-03-2013 31 2   Download

Nitric oxide (NO • ) has been proposed to be a physiological modulator of cell proliferation, able to promote in most cases cell cycle arrest. In this review I explore the molecular basis of this mechanism of action. The mod-ulatory action of NO • on the intracellular concentration of cGMP and the machinery directly involved in the control of cell cycle progression, inclu-ding the expression and activity of diverse cyclins and cyclin-dependent kinases,

16p inspiron33 26-03-2013 49 4   Download

Src homology 2 (SH2) domain-containing protein tyrosine phosphatase-1 (SHP-1) is a critical inhibitory regulator in T cell-receptor (TCR) signaling. However, the exact molecular mechanism underlying this is poorly defined, largely because the physiological substrates for SHP-1 in T cells remain elusive.

11p inspiron33 26-03-2013 33 4   Download

Environmental stress deleteriously affects every aspect of an ectotherm’s biological function. Frequent exposure of terrestrial insects to temperature variation has thus led to the evolution of protective biochemical and phy-siological mechanisms. However, the physiological mechanisms underlying the positive impact of fluctuating thermal regimes (FTRs) on the fitness and survival of cold-exposed insects have not been studied.

9p galaxyss3 21-03-2013 45 6   Download

Adenosylcobalamin-dependent diol and glycerol dehydratases are isofunc-tional enzymes and undergo mechanism-based inactivation by a physiologi-cal substrate glycerol during catalysis. Inactivated holoenzymes are reactivated by their own reactivating factors that mediate the ATP-depen-dent exchange of an enzyme-bound, damaged cofactor for free adenosylco-balamin through intermediary formation of apoenzyme.

11p media19 04-03-2013 36 2   Download

Bacillus subtilishas three active tyrosine kinases, PtkA, PtkB and McsB, which play an important role in the physiology of the bacterium. Genome sequence analysis and biochemical experiments indicated that the ortholog of McsB, BAS0080, is the only active tyrosine kinase present inBacillus anthracis.

11p vinaphone15 28-02-2013 27 2   Download

Sterol regulatory element-binding proteins (SREBPs) have been established as physiological regulators of lipid synthesis. The molecular mechanisms by which cellular sterol balance and nutritional states regulate SREBP acti-vities are the current research focus of this field.

6p vinaphone15 27-02-2013 41 3   Download

An emerging body of evidence supports a key role for the endocannabinoid system in numerous physiological and pathological mechanisms of the cen-tral nervous system. In the recent past, many experimental studies have examined the putative protective or toxic effects of drugs interacting with cannabinoid receptors or have measured the brain levels of endocannabi-noids inin vitro and in vivo models of cerebral ischemia.

11p vinaphone15 27-02-2013 40 3   Download

The prion-forming domain comprising residues 218–289 of the fungal prion HET-s forms infectious amyloid fibrils at physiological pH. Because a high-resolution molecular model for the structure of these fibrils exists, it constitutes an attractive system with which to study the mechanism of amy-loid assembly.

12p vinaphone15 25-02-2013 23 3   Download

Protein-tyrosine phosphatases (PTPs) are regulated by reversible inactivat-ing oxidation of the catalytic-site cysteine. We have previously shown that reversible oxidation upon UVA irradiation is followed by calpain-mediated PTP degradation. Here, we address the mechanism of regulated cleavage and the physiological function of PTP degradation.

12p viettel02 20-02-2013 23 1   Download

Enzymes are basically composed of 20 naturally occurring amino acids, yet they catalyse a dizzying array of chemical reactions, with regiospecificity and stereospecificity and under physiological conditions. In this review, we attempt to gain some understanding of these complex proteins

11p cosis54 09-12-2012 44 2   Download