Therapeutic potentials

The aim of this study was to investigate the potential impact of obesity on patients’ clinical outcome and response to the usual post orthopaedic surgery thromboprophylaxis enoxaparin or aspirin. Additionally, the participants perceived barrier(s) to adherence to the prescribed prophylaxis were explored.

224p runthenight04 02-02-2023 2 1   Download

The nasal route for drug administration has the potential for local and systemic delivery of a wide variety of therapeutics. Nasal spray drug delivery has the potential to administer drugs to the bloodstream, avoiding the use of painful needles. While there is great potential, studies in the area are limited and somewhat conflicting. This study aimed to support the improvement of nasal drug delivery through experimental work on a model nasal cavity and through experimental characterisation of nasal spray behaviour. Four different brands of nasal spray were investigated.

91p runthenight04 02-02-2023 7 3   Download

The nasal route for drug administration has the potential for local and systemic delivery of a wide variety of therapeutics. Nasal spray drug delivery has the potential to administer drugs to the bloodstream, avoiding the use of painful needles. While there is great potential, studies in the area are limited and somewhat conflicting. The thesis "Experimental Studies in Aid of Improving Nasal Drug Delivery" aimed to support the improvement of nasal drug delivery through experimental work on a model nasal cavity and through experimental characterisation of nasal spray behaviour.

91p runordie3 06-07-2022 5 3   Download

A new study reveals comprehensive and unique epigenetic properties of glioma stem cells, leading to novel molecular insights and therapeutic potentials toward glioblastoma multiforme treatment.

3p vimichaelfaraday 25-03-2022 11 1   Download

Esophageal squamous cell carcinoma (ESCC) is the most predominant primary malignant tumor among worldwide, especially in China. To date, the successful treatment remains a mainly clinical challenge, it is imperative to develop successful therapeutic agents.

11p vielonmusk 21-01-2022 17 0   Download

Intrahepatic cholangiocarcinoma (ICC) is a type of malignant tumor ranking the second in the incidence of primary liver cancer following hepatocellular carcinoma. Both the morbidity and mortality have been increasing in recent years. Small duct type of ICC has potential therapeutic targets. But overall, the prognosis of patients with ICC is usually very poor.

12p vielonmusk 21-01-2022 17 1   Download

Biotherapeutics (BTs), one of the fastest growing classes of drug molecules, offer several advantages over the traditional small molecule pharmaceuticals because of their relatively high specificity, low off-target effects, and biocompatible metabolism, in addition to legal and logistic advantages. However, their clinical utility is limited, among other things, by their high immunogenic potential and/or variable therapeutic efficacy in different patient populations.

7p caothientrangnguyen 09-05-2020 22 0   Download

Catalytic antibodies capable of digesting crucial proteins of pathogenic bac-teria have long been sought for potential therapeutic use. Helicobacter pyloriurease plays a crucial role for the survival of this bacterium in the highly acidic conditions of human stomach. The HpU-9 monoclonal anti-body (mAb) raised againstH. pyloriurease recognized thea-subunit of the urease, but only slightly recognized theb-subunit. However, when isolated both the light and the heavy chains of this antibody were mostly bound to the b-subunit....

9p fptmusic 11-04-2013 45 3   Download

a-Conotoxins that target the neuronal nicotinic acetylcho-line receptor have a range of potential therapeutic applica-tions and are valuable probes for examining receptor subtype selectivity. The three-dimensional structures of about half of the knownneuronal specifica-conotoxins have nowbeendeterminedandhaveaconsensus foldcontaininga helical region braced by two conserved disulfide bonds. These disulfide bonds define the two-loop framework char-acteristic for a-conotoxins, CCXmCXnC, where loop 1 comprisesfourresidues(m¼4) and loop 2 between three and seven residues (n¼3, 6 or 7). ...

7p dell39 03-04-2013 42 4   Download

Type IIa bacteriocins, which are isolated from lactic acid bacteria that are useful for food preservation, are potent antimicrobial peptides with considerable potential as therapeutic agents for gastrointestinal infections in mam-mals. They are ribosomally synthesized as precursors with an N-terminal leader, typically 18–24 amino acid residues in length, which is cleaved during export from the produ-cing cell.

9p dell39 03-04-2013 43 5   Download

Behavioral arousal requires integration of multiple neurotransmitter and neuromodulatory systems. Identifying these systems is the key to not only a better understanding of the neurobiology of sleep⁄wakefulness but may also lead to the discovery of potential therapeutic targets for various sleep disorders.

5p dell39 27-03-2013 35 4   Download

Annexin B1 fromCysticercus cellulosaehas recently been identified using immunological screening in an attempt to find novel antigens for vaccine development against cysticercosis. The protein possesses anticoagulant activity and carries significant therapeutic potential due to its thrombus-targeting and thrombolytic properties.

10p inspiron33 25-03-2013 34 5   Download

Cathelicidins are an important family of cationic host defense peptides in vertebrates with both antimicrobial and immunomodulatory activities. Fowlicidin-1 and fowlicidin-2 are two newly identified chicken cathelicidins with potent antibacterial activities. Here we report structural and func-tional characterization of the putatively mature form of the third chicken cathelicidin, fowlicidin-3, for exploration of its therapeutic potential.

11p inspiron33 23-03-2013 40 3   Download

Diaminopelargonic acid aminotransferase (DAPA AT), which is involved in biotin biosynthesis, catalyzes the transamination of 8-amino-7-oxonona-noic acid (KAPA) using S-adenosyl-l-methionine (AdoMet) as amino donor.Mycobacterium tuberculosisDAPA AT, a potential therapeutic tar-get, has been overproduced inEscherichia coliand purified to homogeneity using a single efficient step on a nickel-affinity column.

12p inspiron33 23-03-2013 38 3   Download

Cystine-knot miniproteins are members of a large family of small proteins that are defined by a common structural scaffold which is stabilized by three intramolecular disulfide bonds. Cystine-knot miniproteins display a broad spectrum of therapeutically useful natural biological activities and several family members are marketed as therapeutics or are in clinical development.

7p galaxyss3 07-03-2013 30 4   Download

Characterization of the peptide content of venoms has a number of poten-tial benefits for basic research, clinical diagnosis, development of new therapeutic agents, and production of antiserum. Here, we use a substrate-capture assay that employs a catalytically inactive mutant of thimet oligo-peptidase (EC 3.4.24.15; EP24.15) to identify novel bioactive peptides in Bothrops jararacussu venom.

13p media19 06-03-2013 45 5   Download

This study was undertaken to explore the potential of new therapeutic approaches designed to reactivate cell death pathways in apoptosis-refrac-tory gliomas and to characterize the underlying molecular mechanisms of this reactivation.

12p media19 06-03-2013 37 3   Download

Enzyme enhancement therapy is an emerging therapeutic approach that has the potential to treat many genetic diseases. Candidate diseases are those associated with a mutant protein that has difficulty folding and⁄or assembling into active oligomers in the endoplasmic reticulum.

11p media19 04-03-2013 38 2   Download

Vitamin K2(menaquinone-4, MK-4) has been reported to induce apoptosis in hepatocellular carcinoma, leukemia and myelodysplastic syndrome cell lines. The effects of MK-4 on the development of arthritis have never been addressed thus far. In the present study, we investigated the effect of MK-4 upon the proliferation of rheumatoid synovial cells and the development of arthritis in collagen-induced arthritis.

7p media19 04-03-2013 27 4   Download

X-Linked inhibitor of apoptosis protein (XIAP) is a member of the inhibitor of apoptosis protein family that is overexpressed in human can-cers. There is great interest in the development of XIAP inhibitors, which are predicted to promote apoptosis in cancer cells and thus have therapeutic potential.

11p vinaphone15 28-02-2013 29 2   Download