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Báo cáo khoa học: Structure-activity relationships of a-conotoxins targeting neuronal nicotinic acetylcholine receptors

Chia sẻ: Nguyen Thang | Ngày: | Loại File: PDF | Số trang:7

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a-Conotoxins that target the neuronal nicotinic acetylcho-line receptor have a range of potential therapeutic applica-tions and are valuable probes for examining receptor subtype selectivity. The three-dimensional structures of about half of the knownneuronal specifica-conotoxins have nowbeendeterminedandhaveaconsensus foldcontaininga helical region braced by two conserved disulfide bonds. These disulfide bonds define the two-loop framework char-acteristic for a-conotoxins, CCXmCXnC, where loop 1 comprisesfourresidues(m¼4) and loop 2 between three and seven residues (n¼3, 6 or 7). ...

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Nội dung Text: Báo cáo khoa học: Structure-activity relationships of a-conotoxins targeting neuronal nicotinic acetylcholine receptors

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