Thyroid Hormones

Bayesian kernel machine regression (BKMR) analysis was used to evaluate the univariate contaminant exposure effect as well as the contaminant mixture effects on levels of thyroid hormones. Significant and positive associations were found between total T3 and PC-2 (high positive nickel and cadmium loadings), total T3 and PC-3 (negative association with negative loading for nickel and positive loading for cadmium) and TSH and PC-1 (high positive loadings for organic contaminants).

9p thebadguys 15-01-2022 13 1   Download

Bài giảng với nội dung: trục sinh lý Hypothalamic-pituitary-thyroid; biểu hiệu tim mạch của cường giáp; dấu chứng tim mạch trong cường giáp; cơ chế bệnh sinh bệnh tim cường giáp; tác dụng của hormone giáp trên huyết động tim mạch; tác dụng của hormone giáp trên hệ thống tim mạch và kết cục; nhịp nhanh xoang trong cường giáp; tác dụng hormone giáp trên điều hòa huyết áp...

35p angicungduoc 13-10-2019 55 2   Download

Bài viết nghiên cứu nhằm đánh giá sự biến đổi nồng độ Triiodothyronin (T3), Thyroxin (T4), Thyroid stimulating hormon (TSH) ở bệnh nhân suy thận mạn chưa điều trị thay thế. Qua đó góp phần nâng cao chất lượng sống của người bệnh suy thận mạn, việc điều chỉnh rối loạn của các cơ quan khác trong đó có chức năng tuyến giáp.

7p trieuroger 13-09-2018 92 4   Download

Tuyến giáp nằm ở trước cổ, tiết ra hormone thyroid, có vai trò điều hòa sự phát triển của các cơ quan, thúc đẩy sự trưởng thành, hoạt động của mọi tế bào. Suy giúp hay cường giáp lúc mang thai đều không có lợi cho bà mẹ và thai nhi.

4p inconsolable_2 28-08-2013 48 3   Download

Kỳ II: Chẩn đoán và những phương pháp điều trị Các phương tiện chẩn đoán nguyên nhân vô kinh Bằng các xét nghiệm tương đối đơn giản, chẩn đoán các nguyên nhân vô kinh: có thai, thiểu năng tuyến giáp, u tuyến yên, không rụng trứng. Theo thứ tự: Loại trừ trường hợp có thai: bằng siêu âm tử cung và hai phần phụ, định lượng bêta-HCG trong máu. Kết quả, túi thai trong lòng tử cung, lượng bêta-HCG trong máu tăng trên 25 mUI/ml. Định lượng nồng độ TSH (Thyroid Stimulating Hormone) trong máu: mặc dù, ít gặp người...

4p quanhenguyhiem 19-08-2013 83 3   Download

A cytosolic thyroid-hormone-binding protein (xCTBP), predominantly responsible for the major binding activity of T3 in the cytosol of Xenopus liver, has been shown to be identical to aldehyde dehydrogenase class 1 (ALDH1) [Yamauchi, K., Nakajima, J., Hayashi, H., Horiuchi, R. & Tata, J.R. (1999) J. Biol. Chem. 274, 8460–8469]. Within this paper we surveyed which signaling, and other, compounds affect the thyroid hormone binding activity and aldehyde dehydrogenase activity of recombinant Xenopus ALDH1 (xCTBP/xALDH1) while examining the relationship between these two activities....

8p research12 01-06-2013 38 4   Download

Thyrotropin-releasing hormone receptor (TRHR) has already been cloned in mammals where thyrotropin-releas-inghormone (TRH) isknowntoactasapowerful stimulator of thyroid-stimulating hormone (TSH) secretion. The TRH receptor of amphibians has not yet been characterized, although TRH is specifically important in the adaptation of skin color to environmental changes via the secretion of a-melanocyte-stimulating hormone (a-MSH).

11p research12 23-04-2013 32 4   Download

Activating mutations of the thyroid-stimulating hormone receptor (TSHr) have been identified as a cause of toxic adenomas. Germline-inactivating TSHr mutations have beendescribedas a cause of congenital hypothyroidism. The effects of combining activating and inactivating mutations within a single receptor was studied. The double mutant T477I/P639S contained an activating TSHr mutation (P639S) togetherwithan inactivatingone (T477I). Theother one (I486M/P639S) contained two activating mutations.

9p tumor12 20-04-2013 37 3   Download

The thyrotropin receptor (TSHR) undergoes a cleavage at the cell membrane, leading to a heterodimer, comprising an aextracellular and a b-transmembrane and intracellular subunits, held togetherbydisulfidebonds.Moreover, part of the a-subunit of the receptor is shed from thyroid and transfected L cells.To understand the role of cleavage and shedding, we constructed deletion mutants starting, respectively, at the most N-terminal (S314), and C-terminal (L378) cleavage sites previously mapped, corresponding to free b1orb2-subunits without further modification of receptor structure....

12p tumor12 20-04-2013 37 2   Download

Thyroid hormone has various effects on cell proliferation, growth and apoptosis. To gain more insight into the molecular dynamics caused by thyroid hormone, gene expression in HeLaTRcells that constitutively over-expressed the thyroid hormone receptor (TR) was analyzed. Gene expression profiling of the HeLaTRcells with an oligonucleotide microarray yielded 229 genes whose expression was significantly altered by T3.

10p fptmusic 16-04-2013 36 4   Download

H2O2 generation is a limiting step in thyroid hormone bio-synthesis. Biochemical studies have confirmed that H2O2is generated by a thyroid Ca 2+ /NADPH-dependent oxidase. Decreased H2O2 availability may be another mechanism of inhibition of thyroperoxidase activity produced by thio-ureylene compounds, as propylthiouracil (PTU) and methimazole (MMI) are antioxidant agents. Therefore, we analyzed whether PTU or MMI could scavenge H2O2or inhibit thyroidNADPHoxidase activityin vitro.

6p fptmusic 16-04-2013 47 3   Download

By employing RT-PCR in conjunction with 3¢-RACE, a full-length cDNA encoding a novel zebrafish cytosolic sulfotransferase (SULT) was cloned and sequenced. Sequence analysis revealed that this zebrafish SULT (desig-nated SULT1 ST5) is, at the amino acid sequence level, close to 50% identical to human and dog SULT1B1 (thyroid hormone SULT). A recombinant form of zebrafish SULT1 ST5 was expressed using the pGEX-2TK bacterial expression system and purified from transformed BL21 (DE3) cells.

10p fptmusic 11-04-2013 42 3   Download

The relationship between the structure of the N-terminal sequence of trans-thyretin (TTR) and the binding of thyroid hormone was studied. A recom-binant human TTR and two derivatives of Crocodylus porosusTTRs, one with the N-terminal sequence replaced by that of human TTR (human⁄crocTTR), the other with the N-terminal segment removed (trun-cated crocTTR), were synthesized inPichia pastoris.

11p inspiron33 25-03-2013 34 5   Download

Transthyretin is a tetrameric binding protein involved in the transport of thyroid hormones and in the cotransport of retinol by forming a complex in plasma with retinol-binding protein. In the present study, we report the crystal structure of a macromolecular complex, in which human transthy-retin, human holo-retinol-binding protein and a murine anti-retinol-binding protein Fab are assembled according to a 1 : 2 : 2 stoichiometry.

14p vinaphone15 28-02-2013 42 3   Download

The structure of the thyroid hormone distributor protein, transthyretin, has been highly conserved during the evolution of vertebrates. Over the last decade, studies into the evolution of transthyretin have revealed the exis-tence of a transthyretin homolog, transthyretin-like protein, in all king-doms. Phylogenetic studies have suggested that the transthyretin gene in fact arose as a result of a duplication of the transthyretin-like protein gene in early protochordate evolution.

13p viettel02 20-02-2013 33 2   Download

A survey of the expression of the transthyretin and thyroxine-binding glob-ulin genes in various species during development provides clues as to how the present thyroid hormone distribution network in extracellular compart-ments developed during vertebrate evolution. Albumin may be the ‘oldest’ component of the thyroid hormone distribution network as it is found in the plasma of all vertebrates investigated.

10p viettel02 20-02-2013 34 3   Download

Thyroid hormones are involved in growth and development, particularly of the brain. Thus, it is imperative that these hormones get from their site of synthesis to their sites of action throughout the body and the brain. This role is fulfilled by thyroid hormone distributor proteins. Of particular inter-est is transthyretin, which in mammals is synthesized in the liver, choroid plexus, meninges

15p viettel02 20-02-2013 40 3   Download

Transthyretin is one of the three major thyroid hormone-binding proteins in plasma and⁄or cerebrospinal fluid of vertebrates. It transports retinol via binding to retinol-binding protein, and exists mainly as a homotetrameric protein of55 kDa in plasma. The first 3D structure of transthyretin was an X-ray crystal structure from human transthyretin.

12p viettel02 20-02-2013 33 4   Download

During vertebrate evolution, the N-terminal region of transthyretin (TTR) subunit has undergone a change in both length and hydropathy. This was previously shown to change the binding affinity for thyroid hormones (THs). However, it was not known whether this change affects other functions of TTR. In the present study, the effect of these changes on the binding of TTR to retinol-binding protein (RBP) was determined.

11p cosis54 09-12-2012 46 3   Download

Tuyến giáp nằm ở trước cổ, tiết ra hormone thyroid, có vai trò điều hòa sự phát triển của các cơ quan, thúc đẩy sự trưởng thành, hoạt động của mọi tế bào. Suy giúp hay cường giáp lúc mang thai đều không có lợi cho bà mẹ và thai nhi. Do vậy, cần tránh mang thai khi đang bị bệnh. Tuy nhiên, nếu có thai thfi vẫn có thể dùng thuốc nhằm bảo vệ thai. Suy giáp Biểu hiện Rất mơ hồ, không đặc trưng, dễ nhầm với suy nhược cơ thể: mệt mỏi, buồn ngủ, trí nhớ giảm...

5p nkt_bibo27 23-12-2011 84 3   Download