Using the dock

Csk-binding protein⁄phosphoprotein associated with glycosphingolipid-enriched domains is a transmembrane adaptor protein primarily involved in negative regulation of T-cell activation by recruitment of C-terminal Src kinase (Csk), a protein tyrosine kinase which represses Src kinase activity through C-terminal phosphorylation. Recruitment of Csk occurs via SH2-domain binding to PAG pTyr317, thus, the interaction is highly dependent on phosphorylation performed by the Src family kinase Fyn, which docks onto PAG using a dual-domain binding mode involving both SH3- and SH2-domains of Fyn....

12p research12 29-04-2013 40 3   Download

Although a steadily increasing number of protein±ligand docking experiments have been performed successfully, there are only few studies concerning protein±sugar inter-actions. In this study, we investigate the interaction of wheat germ agglutinin (WGA) withN-acetylglucosamine and a number of its derivatives and predict the binding free ener-gies using ¯exible docking techniques.

7p research12 29-04-2013 35 2   Download

Protein molecular modelling and ligand docking were employed for the design of anthraquinone galactosyl-bio-mimetic dye ligands (galactosyl-mimodyes) for the target enzyme galactose dehydrogenase (GaDH). Using appro-priate modelling methodology, a GaDH model was build based on a glucose-fructose oxidoreductase (GFO) protein template.

15p tumor12 22-04-2013 46 2   Download

NMR spectroscopy and X-ray crystallography have provi-ded important insight into structural features of phenyl-alanine hydroxylase (PAH) and tyrosine hydroxylase (TH). Nevertheless, significant problems such as the substrate specificity of PAHand the different susceptibility of TH to feedback inhibition by L-3,4-dihydroxyphenylalanine (L-DOPA) compared with dopamine (DA) remain unre-solved.

11p tumor12 20-04-2013 51 3   Download

Using NMR spectroscopy and simulated annealing calculations, we deter-mined the solution structure of the disulfide-linked cyclized decapeptide ACLPWSDGPC (SD), which is bound to an anti-(gibberellin A4) mAb 4-B8(8)⁄E9 and was found to be the first peptidyl mimotope for a hydro-phobic ligand. The resulting structure of the peptide showed ab-turn-like conformation in residues three to seven and the region converges well (average rmsd 0.54 A ˚ ).

11p fptmusic 12-04-2013 49 3   Download

The binding characteristics of a series of PPARcligands (GW9662, GI 262570, cis-parinaric acid, 15-deoxy-D 12,14 -prostaglandin J2 , LY171883, indomethacin, linoleic acid, palmitic acid and troglitazone) to human PPARcligand binding domain have been investigated for the first time by using surface plasmon resonance biosensor technology, CD spectroscopyandmoleculardockingsimulation.

12p dell39 03-04-2013 39 4   Download

4.3. Using the Dock Most of the time, you'll use the Dock as either a launcher (you click an icon once to open the corresponding program, file, folder, or disk) or as a status indicator

7p kisiheo 26-07-2010 91 3   Download

Click a program's icon on the Dock, the Sidebar, or the Finder toolbar. Use Spotlight. Hit -Space bar, type the first letters of the program's name, and then press Return or Enter

7p kisiheo 26-07-2010 83 4   Download