Significant function

Data was analyzed based on color-coded themes, which results in four significant findings: (1), the diversity of children’s oral language functions; (2), the Participant and Spectator roles of language in connection to embedded speech and displaced speech; (3), the interaction of Girl Talk and Boy Talk; and (4), the children’s peer support through Zone of Proximal Development.

11p viling 11-10-2024 2 1   Download

The article establishes a correlation function between the load-bearing capacity of traditional steel pipe piles enhanced with two helical plates and the distance of those plates. This analysis focuses on the performance of piles in coral gravelly sand conditions, addressing a significant practical issue with considerable scientific value.

12p viyamanaka 06-02-2025 3 1   Download

Currently, the field of science and technology, particularly Artificial Intelligence (AI), is undergoing significant progress. AI involves the computer-based simulation of human cognitive functions. Within the realm of AI, machine learning, a specialized branch, utilizes mathematical algorithms to enhance computational capabilities.

10p viyamanaka 06-02-2025 3 2   Download

Clavicle fracture is one of the most common injuries of the shoulder girdle. Malunion with angulation or shortening following fractures could cause significant functional deficits of the shoulder. Many kinds of treatment, such as conservative treatments (figure-of-eight bandage, arm sling) or surgeries (fixation with an intramedullary nail, a Kirschner wire, or plates and screws), are described to have their pros and cons for clavicle fractures.

7p vinara 11-01-2025 6 1   Download

Nowadays, there are many factors causing the decrease of male reproductive function such as diet, routine, chemical, ... But some of them have not been paid appropriate attention to, especially the use of paracetamol, which has a significant negative effect on the reproductive process. In this study, we will summarize the results of several studies on the harmful effects of prolonged high-dose use of paracetamol on sperm number, quality, portability and testicular morphology in experimental animals and humans.

15p vinara 11-01-2025 6 1   Download

Cleft lip and palate (CLP) are among the most common congenital defects in the craniofacial region, significantly impacting aesthetics, function, and the psychosocial well-being of both patients and their families. Particularly in cases of wide clefts, the anatomical structures on either side of the cleft are often severely deficient and deformed, complicating surgical procedures.

7p vihatake 06-01-2025 4 2   Download

After studying this chapter, you will be able to: Define leadership and leadership effectiveness Explain why people need leadership Discuss the major obstacles to effective leadership Compare and contrast leadership and management List the roles and functions of leaders and managers Summarize the debate over the role and impact of leadership in organizations.

40p sony_12 25-06-2013 73 8   Download

This thesis focuses on the skills and attributes required by Chief Executive Officers (CEOs) and senior staff as leaders and managers in the residential aged care services (RACS) sector. It makes a significant contribution to this field of inquiry by utilising original research to examine the capabilities needed to meet the challenges faced within this industry sector.

407p runthenight04 02-02-2023 4 3   Download

India has witnessed significant growth in the manufacture of automobiles. Growth in vehicle population results in several environmental issues. Regulators have been controlling the emissions by setting standards.

6p lucastanguyen 01-06-2020 31 3   Download

To assess the clinical significance of electrophysiological, functional, and morphometric studies of the optic nerve in patients with serous meningitis during the recovery period.

8p lucastanguyen 01-06-2020 24 3   Download

CYP73 enzymes are highly conserved cytochromes P450 in plant species that catalyse the regiospecific 4-hydroxylation ofcinnamicacid to formprecursorsofligninandmanyother phenolic compounds. A CYP73A1 homology model based on P450 experimentally solved structures was used to iden-tify active site residues likely togovern substrate binding and regio-specific catalysis. The functional significance of these residues was assessed using site-directedmutagenesis.

12p tumor12 20-04-2013 42 3   Download

The gene encodingBacillus subtilisUMP kinase (pyrH/ smbA) is transcribed in vivo into a functional enzyme, which represents approximately 0.1% of total soluble proteins. The specific activity of the purified enzyme under optimal conditions is 25 unitsÆmg )1 of protein. In the absenceofGTP,theactivityofB. subtilisenzyme is less than 10% of its maximum activity. Only dGTP and 3¢-anthraniloyl-2¢-deoxyguanosine-5¢-triphosphate (Ant-dGTP) can increase catalysis significantly.

9p tumor12 20-04-2013 34 2   Download

Cryptochromes are blue-light photoreceptors sharing sequence similarity to photolyases, a class of flavoenzymes catalyzing repair ofUV-damagedDNAvia electron transfer mechanisms. Despite significant amino acid sequence simi-larity in both catalytic and cofactor-binding domains, cryptochromes lack DNA repair functions associated with photolyases, and the molecular mechanism involved in cryptochrome signaling remains obscure.

8p tumor12 20-04-2013 38 3   Download

The crystal structure of theSchizosaccharomyces pombe Holliday junction resolvase Ydc2 revealed significant struc-tural homology with the Escherichia coliresolvase RuvC but Ydc2 contains a small triple helical bundle that has no equivalent in RuvC.Two of thea-helices that form this bundle show homology to a putative DNA-binding motif known as SAP.To investigate the biochemical function of the triple-helix domain, truncated Ydc2 mutants were expressed inE.coliand in fission yeast.

11p fptmusic 16-04-2013 37 4   Download

In rodents, the olfactory epithelium(OE) canbe divided into four topographically distinct zones, and eachmember of the odorant receptor(OR) gene family is expressed only in one particular zone. To study the functional significance of the zonal structure of the OE, we searched for genes expressed in a zone-specific manner by using the differential display method. Among the clones isolated from the rat OE, we characterized a novel olfactory protein termed O-MACS, a member of the medium-chain acyl-CoA synthetase family....

10p fptmusic 16-04-2013 40 3   Download

Folate is an essential vitamin involved in a number of biological processes. High affinity folate binding proteins (FBPs) exist both as glycosylphospha-tidylinositol-linked, membrane associated folate binding proteins and as soluble FBPs in plasma and some secretory fluids such as milk, saliva and semen. The function and significance of FBPs are unresolved, however, it has been suggested that they may facilitate folate uptake, e.g. during suck-ling.

8p fptmusic 11-04-2013 44 2   Download

Analysis of a draft nuclear genome sequence of the diatomThalassiosira pseudonana revealed the presence of 11 open reading frames showing significant similarity to functionally characterized fatty acid front-end desaturases. The corresponding genes occupy discrete chromosomal loca-tions as determined by comparison with the recently published genome sequence. Phylogenetic analysis showed that two of the T. pseudonana desaturase (Tpdes) sequences grouped with proteobacterial desaturases that lack a fused cytochrome b5 domain. ...

12p fptmusic 11-04-2013 37 2   Download

Whereas most membrane receptors are oligomeric entities, G-protein-coupled receptors have long been thought to function as monomers. Within the last 15 years, accumulating data have indicated that G-protein-coupled receptors can form dimers or even higher ordered oligomers, but the gen-eral functional significance of this phenomena is not yet clear.

9p fptmusic 11-04-2013 39 3   Download

Design, synthesis and characterization of CHAPSTEROL, a novel choles-terol-based detergent developed for functional solubilization of cholesterol-dependent membrane proteins are described. To validate CHAPSTEROL, we employed the oxytocin receptor, a G protein-coupled receptor requiring cholesterol for its high-affinity binding state.

13p awards 05-04-2013 48 3   Download

The protective role of reactive oxygen scavengers against photodamage was studied in isolated photosystem (PS) I submembrane fractions illumin-ated (2000lEÆm )2 Æs )1 ) for various periods at 4
C. The photochemical activity of the submembrane fractions measured as P700 photooxidation was significantly protected in the presence of histidine orn-propyl gallate. Chlorophyll photobleaching resulting in a decrease of absorbance and fluorescence, and a blue-shift of both absorbance and fluorescence maxi-mum in the red region, was also greatly delayed in the presence of these scavengers. ...

0p awards 05-04-2013 60 4   Download