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Báo cáo khoa học: Cleavage of focal adhesion proteins and PKCd during lovastatin-induced apoptosis in spontaneously immortalized rat brain neuroblasts
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We have previously shown that lovastatin induces apoptosis in spontane-ously immortalized rat brain neuroblasts. Focal adhesion proteins and pro-tein kinase Cd(PKCd) have been implicated in the regulation of apoptosis. We found that lovastatin exposure induced focal adhesion kinase, Crk-asso-ciated substrate (p130 Cas ), PKCdcleavage and caspase-3 activation in a con-centration-dependent manner. Lovastatin effects were fully prevented by mevalonate.
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