Báo cáo khoa học: Crystal structures of a bacterial 6-phosphogluconate dehydrogenase reveal aspects of specificity, mechanism and mode of inhibition by analogues of high-energy reaction intermediates
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Crystal structures of recombinantLactococcus lactis6-phosphogluconate dehydrogenase (LlPDH) in complex with substrate, cofactor, product and inhibitors have been determined. LlPDH shares significant sequence iden-tity with the enzymes from sheep liver and the protozoan parasite Trypano-soma bruceifor which structures have been reported.
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