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Báo cáo khoa học: Determinants of the nucleocytoplasmic shuttling of muscle glycogen synthase

Chia sẻ: Nguyen Thang | Ngày: | Loại File: PDF | Số trang:17

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Muscle glycogen synthase (MGS) presents a nuclear speckled pattern in primary cultured human muscle and in 3T3-L1 cells deprived of glucose and with depleted glycogen reserves. Nuclear accumulation of the enzyme correlates inversely with cellular glycogen content. Although the glucose-induced export of MGS from the nucleus to the cytoplasm is blocked by leptomycin B, and therefore mediated by CRM1, no nuclear export signal was identified in the sequence of the protein.

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Nội dung Text: Báo cáo khoa học: Determinants of the nucleocytoplasmic shuttling of muscle glycogen synthase

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