Báo cáo khoa học: Effect of heliquinomycin on the activity of human minichromosome maintenance 4/6/7 helicase
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The antibiotic heliquinomycin, which inhibits cellular DNA replication at a half-maximal inhibitory concentration (IC50) of 1.4–4lm, was found to inhi-bit the DNA helicase activity of the human minichromosome maintenance (MCM) 4/6/7 complex at an IC50value of 2.4lm. In contrast, 14 lmheliqui-nomycin did not inhibit significantly either the DNA helicase activity of the SV40 T antigen and Werner protein or the oligonucleotide displacement activity of human replication protein A.
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