Báo cáo khoa học: Glycation of low-density lipoprotein results in the time-dependent accumulation of cholesteryl esters and apolipoprotein B-100 protein in primary human monocyte-derived macrophages
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Nonenzymatic covalent binding (glycation) of reactive aldehydes (from glu-cose or metabolic processes) to low-density lipoproteins has been previ-ously shown to result in lipid accumulation in a murine macrophage cell line. The formation of such lipid-laden cells is a hallmark of atheroscler-osis.
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