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Báo cáo khoa học: Modulation of F0F1-ATP synthase activity by cyclophilin D regulates matrix adenine nucleotide levels
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Cyclophilin D was recently shown to bind to and decrease the activity of F0F1 -ATP synthase in submitochondrial particles and permeabilized mito-chondria [Giorgio Vet al. (2009) J Biol Chem, 284, 33982–33988]. Cyclo-philin D binding decreased both ATP synthesis and hydrolysis rates.
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