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Báo cáo khoa học: Proteolytic activation of internalized cholera toxin within hepatic endosomes by cathepsin D

Chia sẻ: Nguyen Thang | Ngày: | Loại File: PDF | Số trang:13

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We have defined thein vivo andin vitro metabolic fate of internalized chol-era toxin (CT) in the endosomal apparatus of rat liver. In vivo, CT was internalized and accumulated in endosomes where it underwent degrada-tion in a pH-dependent manner. In vitro proteolysis of CT using an endo-somal lysate required an acidic pH and was sensitive to pepstatin A, an inhibitor of aspartic acid proteases.

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Nội dung Text: Báo cáo khoa học: Proteolytic activation of internalized cholera toxin within hepatic endosomes by cathepsin D

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