Báo cáo khoa học: Regulation of Cyr61/CCN1 gene expression through RhoA GTPase and p38MAPK signaling pathways Role of CREB and AP-1 transcription factors
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Cysteine-rich protein 61 (Cyr61/CCN1) is an angiogenic factor and a member of a family of growth factor-inducible immediate-early genes with functions in cell adhesion, pro-liferation and differentiation.We investigated the regulatory mechanisms and signaling pathways involved inCyr61/ CCN1gene activation in smoothmuscle cells.Treatment of these cells with sphingosine 1-phosphate (S1P), a bioactive lysolipid, increased rapidly but transiently the expression of theCyr61/CCN1gene at both themRNAandprotein levels....
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