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Báo cáo khóa học: Sequence selective binding of bis-daunorubicin WP631 to DNA

Chia sẻ: Nguyen Thang | Ngày: | Loại File: PDF | Số trang:11

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We have used footprinting techniques on a wide range of natural and synthetic footprinting substrates to examine the sequence-selective interaction of the bis-daunorubicin anti-biotic WP631 with DNA. The ligand produces clear DNase I footprints that are very different from those seen with other anthracycline antibiotics such as daunorubicin and nogalamycin. Footprints are found in a diverse range of sequences, many of which are rich inGT (AC) or GA (TC) residues.

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Nội dung Text: Báo cáo khóa học: Sequence selective binding of bis-daunorubicin WP631 to DNA

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