Báo cáo khóa học: Suppression of b1,3galactosyltransferase b3Gal-T5 in cancer cells reduces sialyl-Lewis a and enhances poly N-acetyllactosamines and sialyl-Lewis x on O-glycans Lydia Mare and Marco Trinchera
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We investigated the role ofb3Gal-T5, a member of the b1,3galactosyltransferase (b1,3Gal-T) family, in cancer-associated glycosylation, focusing on the expression of sialyl-Lewis a (sLe a , the epitope of CA19.9 antigen), poly N-acetyllactosamines, and sialyl-Lewis x (sLe x )antigen.A clone permanently expressing an antisense fragment of b3Gal-T5 was obtained from the human pancreas adeno-carcinoma cell line BxPC3 and characterized. Bothb1,3Gal-T activity and sLe a expression are dramatically impaired in the clone. ...
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