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Báo cáo khoa học: The crystal structure of glucose-6-phosphate isomerase from Leishmania mexicana reveals novel active site features

Chia sẻ: Nguyen Thang | Ngày: | Loại File: PDF | Số trang:8

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Glucose-6-phosphate isomerase catalyzes the reversible aldose-ketose isomerization of D-glucose-6-phosphate to D-fructose-6-phosphate in glycolysis and gluconeogenesis, and in the recycling of hexose-6-phosphate in the pentose phosphate pathway. The unicellular protozoans,Trypan-osoma brucei, T. cruziandLeishmaniaspp., of the order Kinetoplastida are important human parasites responsible for African sleeping sickness, Chagas’ disease and leish-maniases, respectively. In these parasites, glycolysis is an important (and in some cases the only) metabolic pathway for ATP supply....

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Nội dung Text: Báo cáo khoa học: The crystal structure of glucose-6-phosphate isomerase from Leishmania mexicana reveals novel active site features

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