Báo cáo khoa học: The diacylglycerol and protein kinase C pathways are not involved in insulin signalling in primary rat hepatocytes
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Diacylglycerol (DAG) andproteinkinase C(PKC) isoforms have been implicated in insulin signalling in muscle and fat cells.We evaluated the involvement ofDAGandPKCin the action of insulin in adult rat hepatocytes culturedwith dexa-methasone, but in the absence of serum, for 48 h. Our results show that although insulin stimulated glycolysis and glycogen synthesis, it had no effect on DAG mass or molecular species composition.
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