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Báo cáo khoa học: The N-acetylglutamate synthase/N-acetylglutamate kinase metabolon of Saccharomyces cerevisiae allows co-ordinated feedback regulation of the first two steps in arginine biosynthesis

Chia sẻ: Nguyen Thang | Ngày: | Loại File: PDF | Số trang:11

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In Saccharomyces cerevisiae, which uses the nonlinear pathway of arginine biosynthesis, the first two enzymes, N-acetylglutamate synthase (NAGS) andN-acetylglutamate kinase (NAGK), are controlled by feedback inhibition. We have previously shown that NAGS andNAGKassociate in a complex, essential to synthase activity and protein level [Abadjieva,A., Pauwels,K.,Hilven, P.&Crabeel,M. (2001) J.Biol.Chem.276, 42869–42880].

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Nội dung Text: Báo cáo khoa học: The N-acetylglutamate synthase/N-acetylglutamate kinase metabolon of Saccharomyces cerevisiae allows co-ordinated feedback regulation of the first two steps in arginine biosynthesis

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