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Báo cáo Y học: Tissue factor pathway inhibitor A possible mechanism of action

Chia sẻ: Nguyen Thang | Ngày: | Loại File: PDF | Số trang:16

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We have analyzed several mathematical models that describe inhibition of the factor VIIa–tissue factor complex (VIIa–TF) by tissue factor pathway inhibitor (TFPI). At the core of these models is a common mechanism of TFPI action suggesting that only the Xa–TFPI complex is the inhibitor of the extrinsic tenase activity. However, the model based on this hypothesis could not explain well all the available experimental data. Here, we show that a good quantitative description of all experimental data could be achieved in a model that contains two more assumptions....

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