Central nervous system

The process of neural stem cell (NSC) differentiation into neurons is crucial for the development of potential cell-centered treatments for central nervous system disorders. However, predicting, identifying, and anticipating this differentiation is complex. In this study, we propose the implementation of a convolutional neural network model for the predictable recognition of NSC fate, utilizing single-cell brightfield images.

7p viengfa 28-10-2024 1 1   Download

Bacterial infections have a substantial impact on global health and can become serious if misdiagnosed with several diseases related to the central nervous, cardiovascular, and respiratory systems. The prognosis in patients with infectious disease strongly depends on early diagnosis and appropriate antibiotic therapy.

8p vifaye 20-09-2024 2 0   Download

In this study, a computational investigation of the physicochemical properties of hypericin and pseudohypericin revealed drug-like characteristics. Pharmacokinetic predictions indicated that hypericin and pseudohypericin are non-toxic to the central nervous system, hepatic system, and cardiac system. Molecular docking results indicated a strong binding affinity of hypericin/pseudohypericin with MPXV thymidylate kinase. As a result, these compounds are being considered as potential Mpox control candidates.

11p xuanphongdacy06 18-09-2024 3 1   Download

In this study, we aim to investigate the serum glucose level in children with epilepsy. Method: A cross-sectional study was conducted at the Pediatric Center of Hue Central Hospital between June 2017 and June 2019. A serum glucose level test was performed after the seizure.

4p vinatisu 29-08-2024 1 1   Download

Melanoma-intrinsic activated β-catenin pathway, the product of the catenin beta 1 (CTNNB1) gene, has been associated with low/absent tumor-infiltrating lymphocytes, accelerated tumor growth, metastases development, and resistance to anti-PD-L1/anti-CTLA-4 agents in mouse melanoma models.

14p vielonmusk 21-01-2022 10 0   Download

High-dose methotrexate (HD-MTX) has broad use in the treatment of central nervous system (CNS) malignancies but confers significant toxicity without inpatient hydration and monitoring. Glucarpidase is a bacterial recombinant enzyme dosed at 50units (u)/kg, resulting in rapid systemic MTX clearance.

10p vielonmusk 21-01-2022 15 1   Download

It is unknown whether and to what degree trials submitted to the US FDA to support drug approval adhere to NCCN guideline-recommended care in their baseline and surveillance CNS imaging protocols. Objective: We sought to characterize the frequency with which the trials cited in US FDA drug approvals for first line advanced NSCLC between 2015 and 2020 deviated from NCCN guideline-recommended care for baseline and surveillance CNS imaging.

8p vielonmusk 21-01-2022 13 0   Download

Regulators of G protein signaling (RGS) proteins modulate G protein-coupled receptor (GPCR) signaling networks by terminating signals produced by active Gα subunits. RGS17, a member of the RZ subfamily of RGS proteins, is typically only expressed in appreciable amounts in the human central nervous system, but previous works have shown that RGS17 expression is selectively upregulated in a number of malignancies, including lung, breast, prostate, and hepatocellular carcinoma.

10p caothientrangnguyen 09-05-2020 12 0   Download

Regulator of G protein signaling (RGS) proteins are gatekeepers regulating the cellular responses induced by G protein-coupled receptor (GPCR)-mediated activation of heterotrimeric G proteins. Specifically, RGS proteins determine the magnitude and duration of GPCR signaling by acting as a GTPase-activating protein for Gα subunits, an activity facilitated by their semiconserved RGS domain. The R7 subfamily of RGS proteins is distinguished by two unique domains, DEP/DHEX and GGL, which mediate membrane targeting and stability of these proteins.

13p caothientrangnguyen 09-05-2020 24 1   Download

Regulator of G-protein signaling (RGS) proteins were originally identified as negative regulators of G-protein-coupled receptor (GPCR) signaling via their GTPase-accelerating protein (GAP) activity. All RGS proteins contain evolutionarily conserved RGS domain; however, they differ in their size and regulatory domains. RGS1 and RGS10 are smaller than other RGS proteins, and their functions involve various inflammatory responses including autoimmune responses in both the periphery and the central nervous system (CNS). Neuroinflammation is the chronic inflammatory response in the CNS.

5p caothientrangnguyen 09-05-2020 24 1   Download

Chapter 12 - The central nervous system (part a), the topics discussed in this chapter are: Central Nervous System (CNS), embryonic development, effect of space restriction on brain development, regions and organization of the CNS, ventricles of the brain,...and other contents.

60p tangtuy07 02-04-2016 38 2   Download

Chapter 12 - The central nervous system (part b), this chapter includes contents: Lateralization of cortical function, cerebral white matter, basal nuclei (ganglia), functions of basal nuclei, diencephalon, thalamus, thalamic function, hypothalamic function,...

45p tangtuy07 02-04-2016 42 2   Download

Chapter 12 - The central nervous system (part c), in this chapter you will learn about the following: Functional brain systems, limbic system, limbic system: emotion and cognition, reticular formation, reticular formation: RAS and motor function, electroencephalogram (EEG), brain waves,...and other contents.

63p tangtuy07 02-04-2016 39 2   Download

After completing this unit, you should be able to: Describe the embryonic development of the spinal cord; describe the gross and microscopic structure of the spinal cord; list the major spinal cord tracts, and classify each as a motor or sensory tract; distinguish between flaccid and spastic paralysis, and between paralysis and paresthesia;...

49p tangtuy07 02-04-2016 47 3   Download

Theo nghĩa sinh học, mạng nơ-ron là một tập hợp các dây thần kinh kết nối với nhau. Ngày nay, thuật ngữ này còn dùng để chỉ mạng nơ-ron nhân tạo, cấu thành từ các nơ-ron nhân tạo. Do đó thuật ngữ 'mạng nơ-ron' xác định hai khái niệm phân biệt: Mạng nơ-ron sinh học là một mạng lưới (plexus) các nơ-ron có kết nối hoặc có liên quan về mặt chức năng trực thuộc hệ thần kinh ngoại biên (peripheral nervous system) hay hệ thần kinh trung ương (central nervous system). Trong ngành thần kinh học...

13p and_12 08-08-2013 85 10   Download

Hu-K4 is a human protein homologous to the K4L protein of vaccinia virus. Due to the presence of two HKD motifs, Hu-K4 was assigned to the family of Phospholipase D proteins although so far no catalytic activity has been shown. The Hu-K4 mRNA is found in many human organs with highest expression levels in the central nervous system. We extended the ORF of Hu-K4 to the 5¢ direction. As a consequence the protein is 53 amino acids larger than originally predicted, now harbouring a putative transmembrane domain....

0p awards 06-04-2013 39 3   Download

Planarians are one of the simplest animal groups with a central nervous system. Their primitive central nervous system produces large quantities of a variety of neuropeptides, of which many are amidated at their C terminus. In vertebrates, peptide amidation is catalyzed by two enzymes [peptidylglycine a-hydroxylating monooxygenase (PHM) and peptidyl-a-hydroxylglycinea-amidating lyase] acting sequentially. In mammals, both enzymatic activities are contained within a single protein that is encoded by a single gene....

14p awards 05-04-2013 41 4   Download

Prion diseases are characterized by the accumulation of a pathogenic mis-folded form of a prion protein (PrP) encoded by the Prnpgene in humans. In the present study in zebrafish, two transcripts and the corresponding genes encoding prion proteins, PrP1 and PrP2, related to human PrP have been characterized with a relatively divergent deduced amino acid sequence, but a well preserved overall organization of structural prion pro-tein motifs.

14p awards 05-04-2013 39 2   Download

The regulation of adenosine kinase (AK) activity has the potential to control intracellular and interstitial adenosine (Ado) concentrations. In an effort to study the role of AK in Ado homeostasis in the central nervous system, two iso-forms of the enzymewere cloned fromamouse brain cDNA library. Following overexpression in bacterial cells, the cor-responding proteins were purified to homogeneity.

9p awards 05-04-2013 37 2   Download

The PAT2 transporter has been shown to act as an electro-genic proton/amino acid symporter. The PAT2 cDNA has been cloned fromvarious human, mouse and rat tissues and belongs to a group of four genes (pat1topat4)withPAT3 and PAT4 still resembling orphan transporters. The first immunolocalization studies demonstrated that the PAT2 protein is found in the murine central nervous system in neuronal cells with a proposed role in the intra and/or intercellular amino acid transport.

8p awards 05-04-2013 53 5   Download