Drug delivery

The results show that the chloroquine phosphate loading process by material consists of two stages: surface adsorption and intra-particle diffusion. The maximum chloroquine phosphate adsorption capacity of the material reached 236 (mg/g) according to the Langmuir model.

8p vikwong 29-09-2024 4 1   Download

Mesoporous silica nanoparticles (MSNs) have been used as an anticancer drug delivery system with high safety and entrapment capacity thanks to their large internal space for drug accommodation, durable structure, and good biocompatibility. However, the treatment efficiency of the bare MSNs is limited due to its drug leakage and burst release. In this study, a phospholipid bilayer was covered on the MSNs surface (MSN@Lip) as a liposomal cap that not only reduced drug leakage but also improved the stability of the colloidal system.

8p dianmotminh02 03-05-2024 7 1   Download

As science and technology has developed, the manner by which drugs can be delivered has grown. Medicines may be taken orally, applied as topical pastes, creams or oils, patches or administered by direct injection to the body. This research explores an alternative method for the delivery of therapeutic compounds to the body. The basis of the study involves the application of traditional medicinal compounds used to cure minor neck and back pains through transdermal topical application, using a textile substrate as the carrier.

128p runthenight07 01-03-2023 10 3   Download

The nasal route for drug administration has the potential for local and systemic delivery of a wide variety of therapeutics. Nasal spray drug delivery has the potential to administer drugs to the bloodstream, avoiding the use of painful needles. While there is great potential, studies in the area are limited and somewhat conflicting. This study aimed to support the improvement of nasal drug delivery through experimental work on a model nasal cavity and through experimental characterisation of nasal spray behaviour. Four different brands of nasal spray were investigated.

91p runthenight04 02-02-2023 7 3   Download

The nasal route for drug administration has the potential for local and systemic delivery of a wide variety of therapeutics. Nasal spray drug delivery has the potential to administer drugs to the bloodstream, avoiding the use of painful needles. While there is great potential, studies in the area are limited and somewhat conflicting. The thesis "Experimental Studies in Aid of Improving Nasal Drug Delivery" aimed to support the improvement of nasal drug delivery through experimental work on a model nasal cavity and through experimental characterisation of nasal spray behaviour.

91p runordie3 06-07-2022 5 3   Download

Research purpose: Preparation and characterization of nanocarrier systems for drug delivery system based on the modification of dendrimer (PAMAM) with biocompatible surfaces such as PNIPAM and PAA to improve the capping cisplatin.

30p extraenglish 24-05-2021 18 4   Download

Research purpose: Preparation and characterization of nanocarrier systems for drug delivery system based on the modification of dendrimer (PAMAM) with biocompatible surfaces such as PNIPAM and PAA to improve the capping cisplatin.

30p capheviahe27 23-02-2021 16 4   Download

Understanding the binding mechanism between gold nanoparticles and biomolecules is a fundamental step for numerous applications in biosensors and targeted drug delivery. This study aims to clarify the adsorption behaviors of CYS and GSH on the gold surface using a small gold Au8 cluster as a model reactant.

9p larachdumlanat127 02-01-2021 12 2   Download

The study has indicated that MOFs has maintained extensive applications in Biological imaging and sensing, Drug delivery systems, Methane storage, Semiconductors, Bio-mimetic mineralization, Carbon capture, Desalination/ion separation, Water vapor capture and Ferroelectrics and Multiferroics.

20p tocectocec 25-05-2020 20 1   Download

The development of drug delivery systems in the last several decades has provided a variety of methods including the synthesis new Pt(II), Pt(IV) complexes, the incorporation of drugs into liposome’s, lipid emulsions, and polymeric micelles to reduce side effects, to increase their solubility, and to prolong circulation time as well. Camphor has bioactivity, it has been used in traditional medicine from time immemorial.

6p abcxyz123_02 03-03-2020 9 1   Download

Nano-cellulose 3D-networks (NA3D) could be produced by Acetobacter xylinum (A. xylinum) living in the fermented aqueous green tea extract. NA3Ds include nano fibers forming networks, which are capable of drug loading to form a prolonged release therapy to improve drug bioavailability.

8p vitheseus2711 28-10-2019 11 0   Download

Rosuvastatin (RSV) là thuốc tổng hợp mới của nhóm statin dùng điều trị rối loạn lipid huyết, tăng cholesterol máu. Do thuộc nhóm II theo hệ thống phân loại sinh dược học nên RSV có tính tan kém, sinh khả dụng thấp (khoảng 20%).Trong số các phương pháp cải thiện tính tan và sinh khả dụng, với nhiều ưu điểm nổi trội, hệ vi tự nhũ (Self Emulsifying Drug Delivery System - SMEDDS) được chọn để nghiên cứu với mục tiêu thành lập công thức SMEDDS chứa RSV với tải lượng cao, ổn định, độ hòa tan, thấm cao và có triển vọng ứng dụng vào thực tiễn.

11p viedison2711 03-09-2019 105 6   Download

Bài viết trình bày về hệ thống chuyển giao thuốc dạng vi tự nhũ (self-microemulsifying drug delivery system, SMEDDS) thường gọi là hệ vi tự nhũ chứa cao diếp cá (DC) toàn phần (SMEDDS-DC) được điều chế nhằm cải thiện độ ổn định của quercitrin - một thành phần có hoạt tính trong cao DC, đồng thời hoạt tính kháng viêm cấp của hệ SMEDDS-DC đã được đánh giá trên mô hình gây viêm bằng carrageenan.

5p hanh_tv25 31-03-2019 35 2   Download

In an attempt to improve material properties used for oral administration, which is restricted by fast dissolution in the stomach, chitosan hydrogels were coated with cellulose dissolved in ionic liquid. Using insulin as a model compound, the properties of these cellulose-coated microparticles for the controlled release of drug were investigated. The results showed that the coated microparticles were more stable than those which were uncoated at low pH and suitable for oral delivery without requiring any harmful and sophisticated cross-linkage treatment.

8p quaymax4 05-09-2018 32 0   Download

Porous metal organic framework nanoscale carriers as a potential platform for drug delivery and imaging, In the domain of health, one important challenge is the efficient delivery of drugs in the body using non-toxic nanocarriers. Most of the existing carrier materials show poor drug loading and or rapid release of the proportion of the drug that is simply adsorbed at the external surface of the nanocarrier.

7p hotrotaitailieu 30-03-2016 74 1   Download

In recent years, many researches have been developing towards biocompatible improvement and cellular penetrating ability of dendrimers in order to use in diagnosis and treatment therapy for several type of cancer. In this study, to enhance biocompatibility, drug loading efficiency and cellular uptake of the polyamidoamine dendrimer, the dendrimer generation 3.0 (G 3.0) was conjugated with hexanoyl chloride and targeted with acid folic (G3.0-C6-FA).

7p tangtuy01 01-03-2016 51 3   Download

Pharmaceutical packaging technology structured to meet the needs of the global market, this volume provides an assessment of a wide range of issues. It covers the entire supply chain from conversion of raw materials into packaging materials and then assembled into product packs. Integrating information from many drug delivery systems, the author discusses testing and evaluation and emphasizes traceability and the need to for additional safeguards.

459p phongluu9x 22-10-2014 82 5   Download

A bio-nanocapsule (BNC), composed of the surface antigen (sAg) of the hepatitis B virus, is an efficient nanomachine with which to accomplish the liver-specific delivery of genes and drugs. Approximately 110 molecules of sAg are associated to form a BNC particle with an average diameter of 130 nm. TheLprotein is an sAg peptide composed mainly of preS and S regions. The preS region, with specific affinity for human hepatocytes, is localized in the N-terminus.

10p fptmusic 11-04-2013 36 2   Download

Polymalic acid is receiving interest as a unique biopolymer of the plasmodia of mycetozoa and recently as a biogenic matrix for the synthesis of devices for drug delivery. The acellular slime moldPhysarum polycephalumis charac-terized by two distinctive growth phases: uninucleated amoebae and multi-nucleated plasmodia.

10p inspiron33 26-03-2013 32 5   Download

Polymeric micelle, the self-assembly of block copolymers with core-shell architecture, is a promising nanocarrier for drug and gene delivery. There are several relevant properties in polymeric micelle as nanocarrier systems, such as longevity in blood circula-tion, tissue-penetrating ability, spatial and temporal controlled drug release, and reduced inherent toxicity of cytotoxic reagents.

6p viettel02 22-02-2013 46 2   Download