Dysfunction

Ostomy has become a common therapy for treating gastrointestinal diseases such as colorectal cancer. Patients with ostomy experience many problems including appearance change, uncontrolled discharge and odour, sexual dysfunction, decreased social functioning, and difficulties taking care of themselves. Because of these problems, many patients with ostomies feel anxious, unconfident and afraid to participate in social activities.

8p vinara 11-01-2025 1 1   Download

The study aimed to identify factors affecting dysfunction in the climacteric women. Materials and Methods: A cross-sectional descriptive study was carried out in 410 menopausal women in Truong An ward, Hue City. The degree of functional disorders in menopause was measured by Menopause Rating Scale (MRS). Yin deficiency and Yang deficiency constitutions were determined by Body Constitution Questionnaire.

7p vihatake 06-01-2025 4 2   Download

Temporomandibular disorders (TMD) are a common medical condition in Vietnam and around the world. Fonseca Anamnestic Index (FAI) is a quick and simple questionnaire to diagnose TMD. Objectives: (1) To evaluate the accuracy and reliability of FAI in the diagnosis of TMD and (2) to suggest adjustments to enhance the clinical value of FAI.

8p viharuno 03-01-2025 2 2   Download

Tài liệu "Hội chứng mạch vành X cardiac syndrome X (Coronary microvascular dysfunction)" phân tích nội dung về định danh hội chứng X, sinh lý bệnh mạch vành (rối loạn chức năng vi mạch, cơ chế thiếu máu cơ tim, cơ chế nhận cảm đau quá mức, cơ chế liên quan giới tính, vai trò của phản ứng viêm, hệ thần kinh tự động) và đưa ra cách điều trị xử trí bệnh mạch vành vi mạch

29p hanh_xuan96 21-11-2018 58 1   Download

Determine acute and subchronic toxicity of TD0014 in experimental animals; evaluate androgenic activity and effects on erectile function of TD0014 in experimental animals; evaluate the effects of TD0014 on sodium valproate-induced reproductive decline in male rats.

27p tamynhan0 15-06-2020 11 2   Download

To describe a case of sequential bilateral adrenal infarction and hemorrhage resulting in an unusual pattern of adrenal function over time.

6p caothientrangnguyen 09-05-2020 12 1   Download

Hầu hết các khó khăn hay tiêu cực trong teamwork đều xuất phát từ 5 nguyên nhân này, nhưng nguyên nhân lớn hơn cả là do lỗi trong quá trình xây dựng đội. Đây chỉ là bản tóm tắt 5 rối loạn chức năng trong teamwork ( The five Dysfunctions of a team )

9p tuyetroimuahe123 12-03-2014 472 16   Download

Ở người cao tuổi vẫn còn có nhu cầu tình dục. Một trong những trở ngại để thực hiện hoạt động tình dục ở người cao tuổi là rối loạn cương dương! Rối loạn cương dương (ED: Erectile Dysfunction) Rối loạn cương dương (RLCD) hay còn gọi là bất lực, là một tình trạng rối loạn với biểu hiện dương vật không thể cương cứng hay không duy trì được sự cương cứng trong quá trình giao hợp. RLCD thường tăng dần theo tuổi tác và ở người cao tuổi có khoảng 15 - 25% bị RLCD. RLCD xảy ra...

3p quanhenguyhiem 19-08-2013 112 15   Download

Mucopolysaccharidosis type I (MPS I) results from a deficiency in the enzyme a-L-iduronidase (IDUA), and is characterized by skeletal abnormalities, hepatosplenomegaly and neurological dysfunction. In this study, we used a late generation lentiviral vector to evaluate the utility of this vector system for the transfer and expression of the human IDUA cDNA in MPS I fibroblasts. We observed that the level of enzyme expression in transduced cells was 1.5-fold the level found in normal cells; the expression persisted for at least two months....

8p system191 01-06-2013 35 5   Download

Obesity is a central feature of the metabolic syndrome and is associated with increased risk for insulin resistance and type II diabetes. Here, we investigated the contribution of human apoliprotein E3 and mouse apoli-protein E to the development of diet-induced obesity in response to western-type diet. Our data show that apolipoprotein E contributes to the development of obesity and other related metabolic disorders, and that human apolipoprotein E3 is more potent than mouse apolipoprotein E in promoting obesity in response to western-type diet. ...

14p research12 29-04-2013 50 3   Download

Anti-Ras intracellular antibodies inhibit cell proliferation in vivo by sequestering the antigen and diverting it from its physiological location [Lener,M.,Horn, I.R.,Cardinale,A., Messina, S., Nielsen, U.B., Rybak, S.M., Hoogenboom, H.R., Cattaneo, A., Biocca, S. (2000)Eur. J. Biochem.267, 1196–1205]. Here we demonstrate that strongly aggregating single-chain antibody fragments (scFv), binding to Ras, induce apoptosis, and this effect is strictly related to the antibody-mediated aggregation of p21Ras.

9p tumor12 20-04-2013 47 3   Download

Aging is accompanied by a gradual deterioration of cell functions. Mitochondrial dysfunction and accumulation of protein damage have been proposed to contribute to this process. The present study was carried out to examine the effects of aging in mitochondrial matrix isolated from rat liver. The activity of Lon protease, an enzyme implicated in the degradation of abnormal matrix proteins, was meas-ured and the accumulation of oxidation and glycoxidation (N e -carboxymethyllysine, CML) products was monitored using immunochemical assays....

8p fptmusic 16-04-2013 31 2   Download

Mitochondrial calcium overload has been implicated in the irreversible damage of reperfused heart. Accordingly, we studied the effect of an oxy-gen-bridged dinuclear ruthenium amine complex (Ru360 ), which is a select-ive and potent mitochondrial calcium uniporter blocker, on mitochondrial dysfunction and on the matrix free-calcium concentration in mitochondria isolated from reperfused rat hearts.

12p fptmusic 11-04-2013 51 2   Download

While cardiac hypertrophy elicited by pathological stimuli eventually leads to cardiac dysfunction, exercise-induced hypertrophy does not. This sug-gests that a beneficial hypertrophic phenotype exists. In search of an under-lying molecular substrate we used microarray technology to identify cardiac gene expression in response to exercise. Rats exercised for seven weeks on a treadmill were characterized by invasive blood pressure mea-surements and echocardiography.

12p awards 06-04-2013 38 3   Download

The double-stranded RNA-dependent protein kinase (PKR) is one of the key mediators of interferon (IFN) action against certain viruses. PKR also plays an important role in signal transduction and immunomodulation. Understanding the regulation of PKR activity is important for the use of PKR as a tool to discover and develop novel therapeutics for viral infec-tions, cancer and immune dysfunction.

0p awards 06-04-2013 28 2   Download

Mutations in the proteina-tropomyosin (Tm) can cause a disease known as familial hypertrophic cardiomyopathy. In order to understand how such mutations lead to protein dysfunction, three point mutations were introduced into cDNA encoding the human skeletal tropomyosin, and the recombinant Tms were produced at high levels in the yeast Pichia pastoris. Two mutations (A63V and K70T) were located in theN-terminal regionofTmandone (E180G)was located close to the calcium-dependent troponin T binding domain....

9p awards 05-04-2013 53 3   Download

Lipid peroxidation and its products such as 4-hydroxy-2-nonenal (HNE) and 4-hydroxyhexenal (HHE) are known to affect redox balance duringagingand various degenerative processes, includingvascular dysfunction. Deterioration of the endothelial cells that line the vascular wall is known to be an underlyingcause of vascular dysfunction. At present, little is known about themechanismbywhichHHE induces endothelial cell death (i.e. apoptosis), although HNE-induced apoptotic cell death has been reported. ...

9p dell39 03-04-2013 26 3   Download

We investigated the changes in the oxidative stress response of yeast cells suffering mitochondrial dysfunction that could impair their viability. First, we demonstrated that cells with this dysfunction rely exclusively on cytosolic thioredoxin peroxidase I (cTPxI) and its reductant sulfiredoxin, among other antioxidant enzymes tested, to protect them against H2O2 -induced death.

12p dell39 27-03-2013 59 4   Download

Huntington’s disease (HD) is a progressive neurodegenerative disorder characterized by multifarious dysfunctional alterations including mitochon-drial impairment. In the present study, the formation of inclusions caused by the mutation of huntingtin protein and its relationship with changes in energy metabolism and with pathological alterations were investigated both in transgenic and 3-nitropropionic acid-treated mouse models for HD.

16p inspiron33 23-03-2013 38 6   Download

Exposure to quartz particles induces a pathological process named silicosis. Alveolar macrophages initiate the disease through their activation, which is the origin of the later dysfunctions. Ascorbic acid is known to selectively dissolve the quartz surface. During the reaction, ascorbic acid progressively disappears and hydroxyl radicals are generated from the quartz surface. These observations may be relevant to mammalian quartz toxicity, as sub-stantial amounts of ascorbic acid are present in the lung epithelium. ...

14p inspiron33 23-03-2013 41 4   Download