In vivo

Preclinical in vivo cancer models are essential tools for investigating tumor progression and response to treatment prior to clinical trials. Although treatment modalities are regularly assessed in mice upon tumor growth in vivo, surgical resection remains challenging, particularly in the orthotopic site. Here, we report a successful surgical resection of glioblastoma (GBM) in patient-derived orthotopic xenografts (PDOXs).

14p vishanshan 27-06-2024 2 1   Download

The present research was designated to investigate the potential of ZnONP nanocomposites as a cancer chemotherapeutic-based drug delivery system and to assess the anti-tumor and anti-inflammatory effectiveness of ZnONP nanocomposites combination with systemic chemotherapeutic drugs doxorubicin (DOX) and folic acid (FA) in Ehrlich ascites carcinoma (EAC) tumor cell line both in vitro and in vivo.

16p vishanshan 27-06-2024 1 1   Download

Bài viết này với mục đích cung cấp cái nhìn tổng quan về sinh học của tóc, các mô hình nghiên cứu trên động vật, đồng thời đánh giá khả năng mọc lại tóc trên in-vitro và invivo, nghiên cứu này mô tả các thiết kế phổ biến cũng như những hạn chế của chúng.

10p vikoch 27-06-2024 3 1   Download

Immunodeficient murine models are usually used as the preclinical models of osteosarcoma. Such models do not effectively simulate the process of tumorigenesis and metastasis. Establishing a suitable animal model for understanding the mechanism of osteosarcoma and the clinical translation is indispensable.

11p vishanshan 27-06-2024 1 1   Download

Cancer-associated fibroblasts (CAFs) play an important role in the tumor microenvironment. Despite the well-known in vitro antitumoral efect of vitamin D3 (VD3), its impact on breast CAFs is almost unknown. In this study, we analyzed the ex vivo effects of calcitriol on CAFs isolated from breast cancer tissues.

25p vikoch 27-06-2024 1 1   Download

Targeted drugs are the main methods of RCC treatment. However, drug resistance is common in RCC patients, in-depth study of the drug-resistant mechanism is essential. Methods We constructed sunitinib resistant and Twist overexpressed A498 cells, and studied its mechanisms in vitro and in vivo.

14p vikoch 27-06-2024 1 1   Download

Orthodontic archwire materials are changing rapidly in our time. Because an ideal archwire material has not yet been found, assessment of the most effectual properties of different archwires including working range and its effect on root resorption is still an unmet clinical need. Unfortunately, most clinical studies lack standardization of subjects and force.

7p visergeyne 18-06-2024 0 0   Download

In this study, we evaluated the impact of breast cancer cells on the characteristics of adipose-derived stem cells (ADSCs) under in vivo conditions. ADSCs were obtained from Balb/c mice three consecutive weeks after transplantation with 1×106 MCF7 cells.

6p viambani 18-06-2024 2 0   Download

This volume provides current methods to analyze the properties of designer receptors exclusively activated by designer drugs (DREADDs) in vitro and to measure the biological responses of DREADD activation in different neuronal populations in vivo. Chapters focus on the utility of DREADD technology to selectively stimulate or inhibit neuronal activity in selected brain areas of transgenic mice.

175p vimeyers 29-05-2024 3 2   Download

Ebook "DNA damage detection in situ, ex vivo, and in vivo: Methods and protocols" presents all major assays used in molecular and cell biology for the labeling of DNA damage in situ, ex vivo, and in vivo. It brings together recently introduced techniques, as well as those established earlier, which detect and quantify DNA damage at the scales ranging from subcellular to the level of a whole, living organism.

328p dongmelo 27-05-2024 6 2   Download

Ebook "Cell–Cell interactions: Methods and protocols" is a versatile collection of readily reproducible cell-cell interaction assays for uncovering cellular interactions at the molecular level, both in vitro and in vivo. The protocols cover a diverse set of cell-cell interaction models in both normal and pathological states, are readily adaptable to nearly any cell type and organ system, and include primary data and outcome analysis.

306p dongmelo 27-05-2024 3 3   Download

Pluchea pteropoda, an annual plant in the Asteraceae family, has traditionally been used in Vietnamese folk medicine as an alternative treatment for high fever, indigestion, and painful and swollen wounds. The present study investigates the acute toxicity and antiinflammatory effects of P. pteropoda aerial parts ethanol extract (EtPP) in animal models. EtPP exhibited no toxicity in mice with a single dose of up to 5000 mg/kg.

5p vicarlos 16-05-2024 0 0   Download

This study, a range of temperatures, lighting periods and salinity levels were examined for cyst hatching. The quality nauplii from optimized cyst hatching conditions were used to determine the toxicity of 26 methanol extracts of 24 poisonous plant species collected from the mountainous regions in Quang Tri province of Vietnam.

13p dianmotminh02 03-05-2024 2 1   Download

Ebook "Modified nucleic acids" spans diverse aspects of modified nucleic acids, from chemical synthesis and spectroscopy to in vivo applications, and highlights studies on chemical modifications of the backbone and nucleobases. Topics discussed include fluorescent pyrimidine and purine analogs, enzymatic approaches to the preparation of modified nucleic acids, emission and electron paramagnetic resonance (EPR) spectroscopy for studying nucleic acid structure and dynamics, non-covalent binding of low- and high-MW ligands to nucleic acids and the design of unnatural base pairs.

280p ladongphongthanh1008 22-04-2024 3 1   Download

Ebook "Primate craniofacial function and biology" is an integrative volume with broad coverage of current research on primate craniofacial biology and function. Topic headings include: the mammalian perspective on primate craniofacial form and function, allometric and comparative morphological studies of primate heads, in vivo research on primate mastication, modeling of the primate masticatory apparatus, primate dental form and function, and palaeoanthropologic studies of primate skulls.

513p tracanhphuonghoa1007 22-04-2024 3 1   Download

Ebook "The cell biology of stem cells" deals with multiple aspects of stem cell biology, ranging from their basic molecular characteristics to the in vivo stem cell trafficking of adult stem cells and the adult stem-cell niche, and ends with a visit to regeneration and cell fate reprogramming.

246p tracanhphuonghoa1007 22-04-2024 2 2   Download

Ebook "Antibacterials (Volume I)" covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level,...

203p tracanhphuonghoa1007 22-04-2024 3 2   Download

Ebook "Small molecule therapeutics for schizophrenia" covers all relevant aspects of drug research, e.g.

327p tracanhphuonghoa1007 22-04-2024 3 3   Download

Bài viết trình bày đánh giá hoạt tính ức chế enzym acetylcholinesterase của viên nén Đan sâm – Tam thất trên mô hình in vitro bằng phương pháp Ellman và đồng thời đánh giá ảnh hưởng của của viên nén Đan sâm – Tam thất đối với trí nhớ dài hạn của chuột nhắt suy giảm trí nhớ bằng scopplamin thông qua thời gian tìm đến chân đế trong mô hình ma trận bơi.

6p vioraclene 16-04-2024 4 2   Download

The heart is one of the least regenerative organs in the human body; adult cardiac myocytes divide at extremely low frequency. Therefore, meaningful induction of cardiac regeneration requires in-depth understanding of myocyte cell-cycle control. Recent insights into how myocytes can be coaxed into duplicating in vivo might inform emerging therapeutics.

3p vibransone 28-03-2024 2 2   Download