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Inflammatory mediators
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Ebook "Complement therapeutics" highlights progress and trends in the rapidly evolving field of complement-related drug discovery and spotlights examples of clinical applications. As an integral part of innate immunity and critical mediator in homeostatic and inflammatory processes, the human complement system has been identified as contributor to a large number of disorders including ocular, cardiovascular, metabolic, autoimmune, and inflammatory diseases as well as in ischemia/reperfusion injury, cancer and sepsis.
323p
ladongphongthanh1008
22-04-2024
3
3
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Ebook "Mesenchymal stem cells and immunomodulation" explores mesenchymal stem cells (MSCs) and their potential to suppress immune-mediated inflammation. The chapters examine applications in autoimmune diseases such as lupus, rheumatoid arthritis and multiple sclerosis; blood cancers such as leukemia and lymphoma; and reproductive complications, specifically pre-term labor and use of MSCs in vitro and in animal models to discover methods of suppressing the causal inflammatory response.
94p
tracanhphuonghoa1007
22-04-2024
3
2
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Systemic sclerosis (SSc) is a genetically complex autoimmune disease mediated by the interplay between genetic and epigenetic factors in a multitude of immune cells, with CD4+ T lymphocytes as one of the principle drivers of pathogenesis.
17p
vibransone
28-03-2024
3
2
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Mast cells are closely associated with epithelium, serving as sentinels responsible for the recognition of tissue injury and coordination of the initial inflammatory response. Upon detection of the injured cell content, mast cells then tailor the release of preformed and newly produced chemical mediators to the detected challenge, via an array of pathogen receptors.
6p
vilazada
31-01-2024
4
2
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Psoriasis is a chronic inflammatory skin disease with a genetic basis. Psoriasis is accepted as a systemic, immune-mediated disease. Hypertension, obesity, metabolic disorders including diabetes mellitus and hyperlipidemia, and psychiatric disorders are more prevalent among children with psoriasis compared to children without psoriasis.
7p
vitiki
30-01-2024
3
2
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Allergic rhinitis is the most common allergic disease, with a prevalence up to 40% in the general population. Allergic rhinitis requires daily treatment to block inflammatory mediators and suppress the inflammatory response.
9p
vitiki
30-01-2024
2
2
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Part 2 book "The feline patient" includes content: Hepatic lipidosis, herpesvirus infection, hyperesthesia syndrome, hypertensive cardiomyopathy, hypertrophic cardiomyopathy, immune mediated hemolytic anemia, inflammatory bowel disease, inflammatory polyps and masses, ischemic encephalopathy, keratitis and conjunctivitis, linear foreign bodies, leprosy syndrome,... and other contents.
430p
muasambanhan04
07-01-2024
4
1
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Part 3 book "Veterinary immunology" includes content: Organ graft rejection and pregnancy; cancer immunology and immunotherapy; autoimmunity; organ specific autoimmune diseases; immune mediated inflammatory diseases; primary immunodeficiencies; secondary immunological defects; drugs and other agents that affect the immune system; immunodiagnostic techniques; evolution of the immune system.
625p
muasambanhan03
02-01-2024
3
2
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The malignant behaviors of lung cancers are affected by not only cancer cells but also many kinds of stromal cells in tumor microenvironment (TME), including macrophages. Macrophages have been proven to extensively influence tumor progression through several mechanisms, among which switching of macrophages from proinflammatory phenotypes (M1-like) to anti-inflammatory phenotypes (M2-like) mediated by transcription factors such as nuclear factor κB (NF-κB) is the most crucial event. The regulation of NF-κB has been well studied, however some details remain fuzzy.
18p
vileonardodavinci
23-12-2023
3
2
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Pyroptosis is a programmed cell death mediated by the gasdermin superfamily, accompanied by inflammatory and immune responses. Exogenously activated pyroptosis is still not well characterized in the tumor microenvironment. Furthermore, whether pyroptosis-related genes (PRGs) in lower-grade glioma (LGG) may be used as a biomarker remains unknown.
19p
vialfrednobel
23-12-2023
4
4
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Chronic obstructive pulmonary disease (COPD) is a common disease which negatively affects living quality and longevity of patients. Unfortunately, current COPD treatments are not radical. COPD is characterized by persistent neutrophil infiltrations mediated by inflammatory cytokines including interleukin (IL)-1β and IL-8 in the airway.
13p
vimulcahy
18-09-2023
4
2
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Gout is an inflammatory type of arthritis caused by the deposition of crystals of monosodium urate monohydrate (MSU) in the joints. The arthritis is mediated by the release of proinflammatory cytokines including IL-1β, TNF-α and IL-6 by leukocytes including macrophages.
6p
vicaptainmarvel
21-04-2023
6
2
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The total methanol extract of whole plants of Anoectochilus roxbughii (Orchidaceae) from Kontum, Vietnam is evaluated to have antibacterial and antioxidant properties. The results indicate that at concentration of 200µg/ml, the extract shows weak activities.
3p
vijaguar
16-11-2022
6
1
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Preeclampsia remains a significant obstetric risk worldwide. The pathophysiology of preeclampsia is complex, with multiple stages involving maladaptations in both placental and maternal physiology. The placenta links the preclinical stage of impaired remodeling of the uterine vasculature, occurring in early pregnancy, to the later clinical stagesm characterised by the maternal syndrome of hypertension and proteinuria.
10p
ngoccthanh
30-06-2022
10
6
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Some studies have demonstrated dexmedetomidine has anti-inflammatory effect on septic rats. However, the mechanism of how dexmedetomidine exerts these effects is still remained unknown. This study was designed to investigate the mechanism of how dexmedetomidine inhibits the production of inflammatory mediators in cecal ligation and puncturinduced septic rats.
6p
viisaacnewton
25-04-2022
7
1
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The predictive value of an individual’s attitude towards painful situations and the status of his immune system for postoperative analgesic requirements are not well understood. These may help the clinician to anticipate individual patient’s needs.
8p
viisaacnewton
25-04-2022
14
1
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To examine whether acute lung injury from direct and indirect origins differ in susceptibility to ventilator-induced lung injury (VILI) and resultant systemic inflammatory responses. During MV more severe lung injury develops after acid instillation as compared to sepsis. HVt causes VILI after acid instillation, but not during sepsis. However, this differential effect was not observed in the systemic release of mediators.
10p
viisaacnewton
26-04-2022
10
1
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Compared to conventional tidal volume ventilation, low tidal-volume ventilation reduces mortality in cased of acute respiratory distress syndrome. The aim of the present study is to determine whether low tidal-volume ventilation reduces the production of inflammatory mediators in the lungs and improves physiological status during hepatic surgery.
9p
viottohahn
30-03-2022
11
1
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Hoof disease is one of the three major diseases that often occur in dairy cows. The impact of this disease on dairy farming is second only to mastitis. Laminitis is a diffuse, aseptic, serous, non-purulent inflammation of the dermal papillae and vascular layers of the cow’s hoof wall.
10p
vigalileogalilei
28-02-2022
10
1
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Feline chronic gingivostomatitis (FCGS) is a multifactorial immune-mediated disease that can lead to chronic pain, anorexia, and weight loss and has substantial health and welfare effects. Currently, the recommended treatment includes dental extractions to decrease the inflammatory stimulation associated with dental plaque.
9p
vigandhi
23-02-2022
6
1
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