CAÙC VIRUS VIEÂM GAN<br />
(Hepatitis viruses)<br />
<br />
PGS. TS. Cao Minh Nga<br />
Boä moân Vi sinh – Khoa Y – ÑHYD TP. HCM<br />
<br />
* Ñònh nghóa<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
Coù tính höôùng TB gan,<br />
Gaây beänh vieâm gan (VG) virus<br />
Hippocrates<br />
<br />
Vieâm gan do caùc virus : Epstein-Barr,<br />
CMV (Cytomegalovirus), virus varicellaZoster vaø virus gaây soát vaøng.<br />
<br />
* Phaân loaïi<br />
<br />
<br />
Coù 6 loaïi virus vieâm gan:<br />
1.<br />
2.<br />
3.<br />
4.<br />
5.<br />
6.<br />
<br />
virus vieâm gan A (HAV),<br />
virus vieâm gan B (HBV),<br />
virus vieâm gan C (HCV),<br />
virus vieâm gan D (HDV taùc nhaân delta),<br />
virus vieâm gan E (HEV),<br />
virus vieâm gan G (HGV).<br />
<br />
VIRUS VIEÂM GAN A (HAV)<br />
<br />
<br />
<br />
<br />
Theá kyû XIX: beänh vaøng da coù tính chaát laây lan.<br />
Theá kyû XX :<br />
- 1973: Feinstone & cs phaùt hieän HAV = KHV e- 1979: Provost & Hilleman nuoâi caáy HAV.<br />
<br />
I. Tính chaát virus (HAV)<br />
1. Caáu truùc:<br />
- HAV: enterovirus tyùp 72 nhoùm Picornavirus.<br />
- Nhaân: 1 chuoãi RNA xoaén oác, M = 2,5x106 , VPG.<br />
<br />
- Capsid hình khoái, 2R = 27 nm , VP1 VP4.<br />
- MBN (-)<br />
- Taêng tröôûng / baøo töông TB.<br />
<br />