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Báo cáo khoa học: Differential effects of RU486 reveal distinct mechanisms for glucocorticoid repression of prostaglandin E2 release
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In A549 pulmonary cells, the dexamethasone- and budeso-nide-dependent repression of interleukin-1b-induced pros-taglandinE2 releasewasmimickedby the steroidantagonist, RU486. Conversely, whereas dexamethasone and budeso-nide were highly effective inhibitors of interleukin-1b-induced cyclooxygenase (COX)/prostaglandin E synthase (PGES) activity and COX-2 expression, RU486 (
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