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Báo cáo Y học: Incorporation of 3-nitrotyrosine into the C-terminus of a-tubulin is reversible and not detrimental to dividing cells

Chia sẻ: Nguyen Thang | Ngày: | Loại File: PDF | Số trang:9

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The C-terminus of thea-chain of tubulin is subject to reversible incorporationof tyrosineby tubulin tyrosine ligase and removal by tubulin carboxypeptidase. Thus, microtu-bules rich in either tyrosinated or detyrosinated tubulin can coexist in the cell. Substitution of the terminal tyrosine by 3-nitrotyrosine has been claimed to cause microtubule dys-function and consequent injury of epithelial lung carcinoma A549 cells. Nitrotyrosine is formed in cells by nitration of tyrosine by nitric oxide-derived species....

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Nội dung Text: Báo cáo Y học: Incorporation of 3-nitrotyrosine into the C-terminus of a-tubulin is reversible and not detrimental to dividing cells

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