Cancer

A novel series of s-triazine derivatives was designed and screened for in silico an cancer activity in histone deacetylase 6 (HDAC6) target by molecular docking method using AutoDock Vina.

10p vifilm 11-10-2024 2 1   Download

Ung thư biểu mô buồng trứng (UTBMBT) tái phát có biểu hiện lâm sàng kém đặc hiệu, chẩn đoán chủ yếu dựa vào cancer antigen 125 (CA-125) và hình ảnh học. Đồng thời, phác đồ điều trị chưa đồng nhất nên chẩn đoán sớm và điều trị hiệu quả UTBMBT tái phát vẫn còn là thách thức. Bài viết trình bày khảo sát đặc điểm lâm sàng, cận lâm sàng và điều trị UTBMBT tái phát tại Bệnh viện Từ Dũ.

7p vifilm 11-10-2024 6 0   Download

To investigate the prevalence of Helicobacter Pylori (H. Pylori) infection by the gastric biopsy for urease test and association with lesion imaging in patients undergoing oesophagogastroduodenoscopy (OGD).

7p viengfa 28-10-2024 3 1   Download

Early prediction of ovarian cancer has not been given much attention, the application of combined models in clinical practice is not widespread, and the calculation of these models is still difficult due to the complexity and multiple variables.

8p viengfa 23-10-2024 6 1   Download

Platinum-based doublet chemotherapy is still supposed as standard regimen in ovarian cancer. However, the rate of relapse or refractory is also very high and vary from 80-85% with stage IIIIV ovarian cancer. The prognosis of platinum-resistant ovarian cancer (relapse or refractory within 6 months after initial treatment) has a median survival of 9–12 months and less than 15% respond to subsequent chemotherapy.

4p visarada 28-03-2025 3 0   Download

Adherence to adjuvant endocrine therapy plays an important role in the treatment of breast cancer. The study's objective was to assess the current status of adherence to adjuvant endocrine therapy in breast cancer patients and analyze some related factors.

7p vimitsuki 30-03-2025 1 0   Download

The mean age of the patients was 63 years. The average operative time was 241.84 ± 65.66 minutes. The average blood loss was 102.94 ± 32.26ml. The average hospitalization time was 16.18 ± 5.14 days. The rate of patients with early complications after surgery was 5.9%, there are 2 cases of anastomotic leaks (3,9%) and be treated with surgery. The average number of lymphadenectomy was 4.50 ± 4.26 nodes.

7p vimaito 28-03-2025 0 0   Download

Bài viết trình bày u thần kinh nội tiết tiêu hóa-tuỵ (Gastroenteropancreatic Neuroendocrine Tumors hay GEP-NETs) là nhóm khối u hiếm gặp nhưng có độ phức tạp cao trong chẩn đoán và điều trị. AJCC (American Joint Committee on Cancer) đã cập nhật hệ thống phân giai đoạn phiên bản 9 vào năm 2023 nhằm cải thiện tiên lượng và quản lý bệnh nhân GEP-NETs.

8p vimaito 28-03-2025 4 1   Download

Bài viết trình bày mục tiêu: Đánh giá kết quả điều trị của người bệnh ung thư thanh quản (UTTQ) giai đoạn tiến triển đã được phẫu thuật cắt thanh quản toàn phần (TQTP). Phương pháp: Tất cả người bệnh ung thư thanh quản giai đoạn T3, T4a, T4b đã phẫu thuật cắt thanh quản toàn phần tại Bệnh viện Đại học Y Dược TP.HCM từ năm 2018 đến 2021.

5p vimaito 28-03-2025 7 1   Download

A fragment-based approach has been applied to derive 2-(7-hydroxy-2-oxo-2H-chromen-4- yl)acetic acid 1 into 4 new coumarin derivatives 2a-d through amide bonds. The compounds were screened for their anticancer activity using MTT assay on MCF-7 and HepG2 cell lines.

10p viaburame 14-03-2025 4 0   Download

Garlic has been utilized since ancient times for both culinary and medicinal purposes. Recent research has identified selenium compounds in garlic, including γ-Glutamyl-Se-methylselenocysteine (GGMSC), leading to the hypothesis that GGMSC acts as a carrier for Se-methylselenocysteine (MSC). Experiments conducted on animals by researchers indicate that the effects of GGMSC in garlic and MSC on cancer cells in experimental models are equivalent. This finding suggests that garlic is a potential chemotherapeutic agent to enhance cancer treatment.

5p tuongmotranh 18-03-2025 3 1   Download

A benzothiazole ring plays an important role in pharmacological target diseases, including metabolic diseases, cancer, anti-inflammatory, neurodegeneration, viral diseases, bacterial infections, fibrosis, and thrombosis. Hydrazone-hydrazide derivatives are present in numerous biological molecules and play a significant role in medicine and pharmacology.

9p viaburame 14-03-2025 2 1   Download

Breast cancer is the most common malignancy and the second leading cause of death in women. While tamoxifen (TAM) remains to be a first-line agent for prevention and treatment of estrogenreceptor (ER) positive breast tumors, TAM resistance represents one of the biggest clinical challenges in breast cancer therapy.

9p vihyuga 04-03-2025 3 1   Download

Quantitative reverse transcription PCR (RT-qPCR) paired with stem-loop was utilized in this study to establish a process for detecting miRNA-425-5p in human plasma, contributing to accurate prognosis and early diagnosis of genetic diseases in humans, especially cancer diseases. Blood samples (n=12) collected from healthy volunteers in Ho Chi Minh City, were subjected to plasma extraction and then microRNA (miRNAs) isolation using the TRIzol method.

11p vihyuga 04-03-2025 6 1   Download

To evaluate the nursing care outcomes in patients with spondylolisthesis who underwent lumbar interbody fusion at Thai Binh General Hospital from January 2022 to January 2024. Method: A prospective descriptive study was conducted among 81 patients diagnosed with lumbar spondylolisthesis and operated on at the Neurospine Surgery Department of Thai Binh General Hospital.

5p viyamanaka 06-02-2025 2 1   Download

To describe the knowledge, attitude, and practices of cervical cancer prevention among female nursing students at Thai Binh University of Medicine and Pharmacy in the academic year 2022-2023.

6p viyamanaka 06-02-2025 2 1   Download

This study aims to present a case of pneumonitis in a patient treated with concurrent chemoradiotherapy (cCRT) followed by durvalumab, focusing on the clinical manifestations, management strategies, and the implications for medical practice.

6p viyamanaka 06-02-2025 6 2   Download

A retrospective study of 61 patients was conducted to evaluate the preliminary results of maximal cytoreductive surgery following neoadjuvant chemotherapy for FIGO stage IIIC-IV ovarian cancer from 2019 to 2023.

8p viyamanaka 06-02-2025 3 2   Download

Prostate cancer (PC) with bone metastasis has many clinical symptoms that very much affected to the patient’s quality of life (QoL). Improving cancer patient’s QoL is a mission for the health care professional workers. The study using questionaires SF-36 and UCLA-PCI-SF- a simple and common methods to evaluate the progress of orchiectomy treatment for bone metastases PC to assess the QoL and prostate-specific functions before and after orchiectomy.

7p viyamanaka 06-02-2025 3 2   Download

Tài liệu này mô tả tình trạng bướu (T/N/M và giai đoạn) trong hướng dẫn điều trị này dựa theo phân loại hợp nhất của 3 tổ chức UICC (the Union Internationale Contre le Cancer), AJCC (the Americian Joint Committee on Cancer), JGCA (Japanese Gastric Cancer Association) được áp dụng 2010. Mời các bạn cùng tham khảo!

10p tuetuebinhan666 06-02-2025 5 2   Download