![](images/graphics/blank.gif)
DNA Polymerase
-
Bài viết tiến hành thu các mẫu gốc lông của bò để tách chiết DNA tổng số. Nghiên cứu này được thực hiện nhằm tối ưu hoá các điều kiện PCR trong khuếch đại đoạn gen LEP và TG5 với DNA tổng số từ gốc lông bò.
7p
gaupanda041
11-07-2024
0
0
Download
-
Esophageal cancer (EC) is a deadly disease with limited therapeutic options. Although circulating tumor DNA (ctDNA) could be a promising tool in this regard, the availiable evidence is limited. We performed a systematic review and meta-analysis to summarize the clinical applicability of the next-generation sequencing (NGS) and droplet digital polymerase chain reaction (ddPCR) technology on the ctDNA detection of the EC and listed the current challenges.
12p
vikoch
27-06-2024
1
1
Download
-
Ebook "DNA damage detection in situ, ex vivo, and in vivo: Methods and protocols" presents all major assays used in molecular and cell biology for the labeling of DNA damage in situ, ex vivo, and in vivo. It brings together recently introduced techniques, as well as those established earlier, which detect and quantify DNA damage at the scales ranging from subcellular to the level of a whole, living organism.
328p
dongmelo
27-05-2024
7
2
Download
-
Trong nghiên cứu này, chúng tôi cung cấp các dẫn liệu được phân tích từ các mẫu cá thu ở khe Kiền để xác định loài L. pellegrini dựa trên phân tích quan hệ di truyền của ba locus mã vạch DNA Cybt, ND2, 16S, chúng tôi thu được với các trình tự Cybt, ND2, 16S đã công bố trên GenBank.
8p
viritesh
02-04-2024
5
1
Download
-
The discovery of synthetic lethal interactions between poly (ADP-ribose) polymerase (PARP) inhibitors and BRCA genes, which are involved in homologous recombination, led to the approval of PARP inhibition as a monotherapy for patients with BRCA1/2-mutated breast or ovarian cancer.
12p
vibransone
28-03-2024
3
2
Download
-
Ebook "DNA replication - Damage from environmental carcinogens" reviews the main concepts concerning DNA damage due to environmental carcinogens, the effects of DNA damage on DNA replication using a single DNA polymerase or DNA replisome, and the effects of carcinogens on various cell activities. It also introduces the detailed protocols for bypassing DNA damage. As we know, various environmental carcinogens are produced as a result of industry, agriculture, chemical engineering and vehicle exhaust in our daily life.
51p
manmanthanhla0201
26-02-2024
2
1
Download
-
To analyze the incidence and risk of hypertension associated with poly(adenosine diphosphate-ribose) polymerase (PARP) inhibitors in cancer patients and provide reference for clinicians.
17p
vischultz
20-10-2023
2
1
Download
-
The association involving mismatch repair (MMR) genes, molecular subtype and specific immune cell group in tumor microenvironment has been focused by more recent studies. Its prognosis value in lung adenocarcinoma (LUAD) neoadjuvant chemotherapy remains elusive.
12p
visharma
20-10-2023
3
2
Download
-
Endometrial cancer (EC) arises from uterine endometrium tissue and is the most prevalent cancer of the female reproductive tract in developed countries. It has been predicted that the global prevalence of EC will increase in part because of its positive association with economic growth and lifestyle.
15p
visharma
20-10-2023
4
2
Download
-
Part 1 book "PCR Protocols" includes content: Long range PCR with a DNA polymerase fusion, isolation of genomic insertion sites of proviruses using splinkerette PCR based procedures, lariat dependent nested PCR for flanking sequence determination, a global single-Cell cDNA amplification method for quantitative microarray analysis,...and other contents.
171p
oursky06
17-10-2023
5
1
Download
-
Luận án Tiến sĩ Y học "Nghiên cứu tính đa hình thái đơn nucleotid (SNP) và đột biến một số gen trong ung thư buồng trứng" trình bày các nội dung chính sau: Xác định đột biến gen BRCA1, BRCA2 ở bệnh nhân ung thư buồng trứng và mối liên quan với mô bệnh học; Xác định một số dạng đa hình thái đơn nucleotid (SNP) trên gen XRCC3, RAD51 có liên quan đến nguy cơ mắc ung thư buồng trứng.
190p
vimurdoch
02-10-2023
11
8
Download
-
Endometrial Cancer (EC) is one of the most prevalent malignancies that affect the female population globally. In the context of immunotherapy, Tumor Mutation Burden (TMB) in the DNA polymerase epsilon (POLE) subtype of this cancer holds promise as a viable therapeutic target.
13p
vioracle
29-09-2023
3
2
Download
-
Inhibitors of Poly (ADP-Ribose) Polymerases (PARP) provide clinical benefit to patients with breast and ovarian cancers, by compromising the DNA repair activity of cancer cells. Although these agents extend progressionfree survival in many patients, responses can be short lived with many patients ultimately progressing.
14p
vioracle
29-09-2023
4
2
Download
-
A molecular docking study of three natural acridones, namely citrusinine-I, 5-hydroxynoracronycin, and paratrimerin C on a target enzyme DNA polymerase μ (Pol μ), was performed. In addition, the hydrogen peroxide anion (HOO─ ), a model radical, and delavirdine, a synthetic drug, are used as ligands for docking on this target protein to investigate the activity of the selected compounds to protect Pol μ protein against their harmful effects.
7p
nhanchienthien
25-07-2023
3
2
Download
-
To develop a method using polymerase chain reaction with confronting two-pair primers (PCR-CTPP) to genotype MTHFR rs1801133 polymorphism in Vietnamese people. Methods: Fifteen DNA samples from a group of Vietnamese people were used to evaluate this assay. The Sanger sequencing method was used to identify the standard genotypes of the rs1801133 polymorphism.
7p
viwhitewolf
11-07-2023
1
1
Download
-
Since its first outbreak, African swine fever (ASF) is always a serious concern to global pig production. The disease is caused by the African swine fever virus (ASFV) that has a mortality rate reaching 100 %. Due to the lack of commercial vaccines, an accurate and fast diagnosis is crucial to control outbreaks.
10p
vimalfoy
08-02-2023
6
1
Download
-
POLG, located on nuclear chromosome 15, encodes the DNA polymerase γ(Pol γ). Pol γ is responsible for the replication and repair of mitochondrial DNA (mtDNA). Pol γ is the only DNA polymerase found in mitochondria for most animal cells. Mutations in POLG are the most common single-gene cause of diseases of mitochondria and have been mapped over the coding region of the POLG ORF.
16p
vihagrid
30-01-2023
5
3
Download
-
In this study, we investigated the protection of EGCG for DNA single strand breaks in irradiated cells using primers for amplification of RNA polymerase, an enzyme responsible to synthesis of mRNA from the damaged DNA, through its down-regulated capacity.
4p
vidumbledore
06-01-2023
10
2
Download
-
Protein purification by affinity chromatography relies primarily on the interaction of a fused-tag to the protein of interest. Here, we describe a tag-free affinity method that employs functional selection interactions to a broad range of proteins.
9p
viginny
23-12-2022
12
3
Download
-
DNA polymerase delta 1 catalytic subunit (POLD1) plays a key role in DNA replication and damage repair. A defective DNA proofreading function caused by POLD1 mutation contributes to carcinogenesis, while POLD1 overexpression predicts poor prognosis in cancers.
16p
viangelamerkel
27-07-2022
8
2
Download
CHỦ ĐỀ BẠN MUỐN TÌM
![](images/graphics/blank.gif)