Molecular

Resveratrol is a naturally occurring compound with anti-inflammatory properties. However, the protective molecular mechanisms of resveratrol against LPS-induced inflammation have not been thoroughly known. In the present study, we examined the antiinflammatory effect of resveratrol in inflammatory model using murine macrophage-like cell RAW264.7 stimulated with LPS. Resveratrol suppressed the production of inflammatory cytokines in LPS-stimulated RAW264.7 cells with the IC50 value as 17.5 ± 0.7 μM for IL-6, 14.2 ± 1.9 μM for IL-10, and 18.9 ± 0.6 μM for TNF-α.

9p xuanphongdacy06 18-09-2024 1 1   Download

In this study, a computational investigation of the physicochemical properties of hypericin and pseudohypericin revealed drug-like characteristics. Pharmacokinetic predictions indicated that hypericin and pseudohypericin are non-toxic to the central nervous system, hepatic system, and cardiac system. Molecular docking results indicated a strong binding affinity of hypericin/pseudohypericin with MPXV thymidylate kinase. As a result, these compounds are being considered as potential Mpox control candidates.

11p xuanphongdacy06 18-09-2024 3 1   Download

In this research, Molecular Dynamics (MD) simulations were conducted to explore the temperature effect on the microstructure and phase transition of the Ag0.25Au0.75 alloy. The findings reveal that as the temperature rises, the material's phase transition switches from crystalline to liquid and vice versa.

9p viengfa 28-10-2024 5 1   Download

In this study, 2D-QSAR analysis and molecular docking were performed to investigate the relationship between the hydroxamatebased HDAC inhibitors with benzimidazole scaffold and the activity toward HDAC6. A dataset of 55 N-hydroxybenzamide, Nhydroxypropenamide derivatives containing benzimidazole structure with HDAC6 in vitro activity were collected.

8p vihyuga 04-03-2025 2 1   Download

Acetylcholinesterase (AChE) has been one of the important and potential targets in the discovery, and development of new drugs for treating and slowing the progression of Alzheimer's disease (AD). This research suggests potential structural frameworks for synthesizing AChE inhibitor derivatives for treating AD.

11p vihyuga 04-03-2025 1 1   Download

Chamaecrista pumila has empirically been used to treat inflammation-associated complications. However, the molecular mechanism and chemical components underlying the anti-inflammatory activity of this medicinal plant are poorly understood. Hence, the present study aimed to identify main bioactive compounds from the ethyl acetate fraction of C. pumila extract, which was demonstrated to possess the strongest anti-inflammatory effect in a previous study, and provide mechanistic insights into modulation of inflammatory responses by the compound of interest.

13p vihyuga 04-03-2025 1 1   Download

This study aimed to design novel Glutaminyl Cyclase (QC) inhibitors based on 2D-QSAR study, ligand-based pharmacophore modeling and molecular docking. A 2D-QSAR model was developed from a dataset of 1681 QC inhibitors by using Support Vector Regression (SVR) algorithm with 256-bit Morgan fingerprints.

17p vihyuga 04-03-2025 3 1   Download

This study aims to generate the system of histone deacetylase enzymes (HDAC) with its cofactor zinc ion using two different parameter models and application of molecular dynamic (MD) study for structure of HDAC2 and vorinostat ligand. Materials and methods: Two non-bonded models, including 12-6-4 Lennard-Jones and cationic dummy atom, were applied for building a solvation system of HDAC2 crystal structure with presence of suber-anilohydroxamic acid (SAHA) and zinc ion.

9p vihyuga 04-03-2025 3 1   Download

IHC has became an indispensable tool adjunct to the conventional pathology in daily practice. This technique is called immunohistochemistry because it was combined by two aspects including immunology and histochemistry applied directly on the tissue (taken from the patient lesion) section embedded in paraffin.

4p viuchiha 06-01-2025 1 1   Download

Leukemia is the most common childhood cancer in both Vietnam and another country around the world. Although the rate of successful treatment has increased due to the improvements of therapy and supportive care, the rate of relapse is still high.

5p viuchiha 06-01-2025 5 1   Download

InfluenzaA (H1N1) 2009 virus caused the pandemic worldwide and in Vietnam, the outbreak occurred after a case imported from the U.S. Our study provided the data on viral diagnosis and molecular epidemiology of influenza H1N1 2009 virus isolated in Thua Thien Hue, central of Vietnam.

9p viuchiha 06-01-2025 1 1   Download

Hemoglobinopathy is the most common monogenic disease worldwide. The aims of the current study were: (1) to investigate some hematological characteristics of patients with hemoglobinopathies; and (2) to detect the mutation of α-globin and β-globin genes, as well as the association between genotype and degree of anemia.

8p viharuno 03-01-2025 6 2   Download

In this study, we assessed the status of antibiotic resistance of H. pylori isolates to antimicrobial agents at Hospital of Hue University of Medicine and Pharmacy in Central Vietnam and identified the underlying molecular mechanisms related to tetracycline and amoxicillin resistance.

8p viharuno 03-01-2025 4 2   Download

Spermatogenesis is a complex process involving mitotic cell division, meiosis, and spermiogenesis. This study aimed to examine the therapeutic effects and mechanisms of Panax ginseng in improving spermatogenesis, using a systematic network pharmacology approach and molecular docking.

14p viharuno 03-01-2025 6 2   Download

Methicillin-resistant Staphylococcus aureus (MRSA) is one of the most predominant agents that cause nosocomial infections. Objectives: To determine the rate of MRSA and the molecular characteristics of the coagulase encoding gene of these isolates based on polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP).

6p viuchiha 03-01-2025 3 2   Download

In this study, the adsorption configuration, adsorption energy of toxic gas molecules (CO, NO, CO2, NH3, and NO2) on B12 – borophene was investigated by first – principle calculations using three van der Waals correlation functionals: RevPBE-vdW, optPBE-vdW, and vdW-DF2.

65p nienniennhuy77 31-12-2024 5 2   Download

Một axít nucleic là một đại phân tử sinh học có phân tử lượng lớn (tiếng Anh: high-molecular-weight biochemichal macromolecule) được cấu tạo từ các chuỗi nucleotide nhằm truyền tải thông tin di truyền (genetic information). Hai loại axít nucleic phổ biến nhất là deoxyribonucleic acid (ADN) và ribonucleic acid (ARN). Axít nucleic có mặt ở hầu hết các tế bào sống và virút.Tên gọi axít nucleic có từ sự xuất hiện phổ biến của nó trong nhân tế bào, là tên gọi chung của họ các cao phân tử sinh học biopolymers. Các đơn phân monomer còn được gọi...

68p primrose040390 09-03-2010 899 156   Download

Is a branch of polymer science dealing with analysis and characterisation of polymers. üThe complication of macromolecular chains, the dispersion in molecular weight, tacticity, crystallinity, orientation, composition of polymers etc. and complex morphological systems ⇒ analysis of polymer ≠ the small organic materials ⇒ Focus on viscoelastic properties, dynamic mechanical testing.

114p buitiendung87 06-01-2011 345 154   Download

Khuếch tán Nếu chuyển động ngẫu nhiên xảy ra dưới tác động sự trao đổi vị trí của các phân tử do tính chất nhiệt động học thì quá trình này gọi là khuếch tán phân tử (Molecular diffusion). Nếu chuyển động ngẫu nhiên do sự rối thì quá trình này gọi là khuếch tán xoáy

40p northernlight 24-07-2011 197 65   Download

Basic Cell Biology I. Cytoplasm A. Plasma membrane B. Mitochondria C. Ribosomes D. Endoplasmic reticulum 1. Rough 2. Smooth E. Golgi apparatus F. Lysosomes G. Cytoskeleton II. Nucleus A. Nuclear Envelope B. Chromatin C. Nucleolus D. Nuclear matrix III. Cell division .© 2002 by Bruce Alberts, Alexander Johnson, Julian Lewis, Martin Raff, Keith Roberts, and Peter Walter. .Asymmetrical arrangement of phospholipids in plasma membrane ATP-dependent phospholipid translocase .Molecular Cell Biology, Lodish et al., 4th edition. .Figure 2—1.

68p whitedaisy1010 26-02-2013 63 12   Download