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Báo cáo khoa học: by nucleotide affinity cleavage: a distinct nucleotide specificity of the C-terminal ATP-binding site

Chia sẻ: Nguyen Thang | Ngày: | Loại File: PDF | Số trang:8

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The 90-kDa heat shock protein (Hsp90) is a molecular chaperone that assists both in ATP-independent sequestra-tion of damaged proteins, and inATP-dependent folding of numerous targets, such as nuclear hormone receptors and protein kinases. Recent work from our lab and others has established the existence of a second, C-terminal nucleotide bindingsite besides the well characterized N-terminal, gel-danamycin-sensitive ATP-bindingsite.

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Nội dung Text: Báo cáo khoa học: by nucleotide affinity cleavage: a distinct nucleotide specificity of the C-terminal ATP-binding site

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