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Báo cáo khoa học: Shedding of the amyloid precursor protein-like protein APLP2 by disintegrin-metalloproteinases Retinoic acid-induced upregulation of substrate and proteinase ADAM10 during neuronal cell differentiation

Chia sẻ: Nguyen Thang | Ngày: | Loại File: PDF | Số trang:13

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Cleavage of the amyloid precursor protein (APP) within the amyloid-beta (Ab) sequence by the a-secretase prevents the formation of toxic Abpep-tides. It has been shown that the disintegrin-metalloproteinases ADAM10 and TACE (ADAM17) act asa-secretases and stimulate the generation of a soluble neuroprotective fragment of APP, APPsa.

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Nội dung Text: Báo cáo khoa học: Shedding of the amyloid precursor protein-like protein APLP2 by disintegrin-metalloproteinases Retinoic acid-induced upregulation of substrate and proteinase ADAM10 during neuronal cell differentiation

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