Báo cáo khoa học: Substrate and inhibitor specificity of Mycobacterium avium dihydrofolate reductase
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Dihydrofolate reductase (EC 1.5.1.3) is a key enzyme in the folate biosyn-thetic pathway. Information regarding key residues in the dihydrofolate-binding site ofMycobacterium aviumdihydrofolate reductase is lacking. On the basis of previous information, Asp31 and Leu32 were selected as resi-dues that are potentially important in interactions with dihydrofolate and antifolates (e.g. trimethoprim), respectively.
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