Estrogen

Based on promising phase II data, the histone deacetylase inhibitor entinostat is in phase III trials for patients with metastatic estrogen receptor-positive breast cancer. Predictors of sensitivity and resistance, however, remain unknown.

14p vibransone 28-03-2024 4 2   Download

Estrogen receptor (ER) activity is critical for the development and progression of the majority of breast cancers. It is known that ER is differentially bound to DNA leading to transcriptomic and phenotypic changes in different breast cancer models.

11p vioraclene 31-03-2024 4 2   Download

Phenotypic changes during cancer progression are associated with alterations in gene expression, which can be exploited to build molecular signatures for tumor stage identification and prognosis. However, it is not yet known whether the relative abundance of transcript isoforms may be informative for clinical stage and survival.

14p vioraclene 31-03-2024 2 2   Download

Normal cell BRCA1 epimutations have been associated with increased risk of triple-negative breast cancer (TNBC). However, the fraction of TNBCs that may have BRCA1 epimutations as their underlying cause is unknown. Neither are the time of occurrence and the potential inheritance patterns of BRCA1 epimutations established.

15p vicwell 29-02-2024 3 1   Download

Ebook "Q’eqchi’ maya reproductive ethnomedicine" have an extensive pharmacopoeia of medicinal plants used traditionally for reproductive health and fertility, utilizing more than 60 plant species for these health treatments. Ten species were selected for investigation of their estrogenic activity using a reporter gene assay. Nine of the species were estrogenic, four of the species were also antiestrogenic, and two of the extracts were cytotoxic to the MCF-7 breast cancer cell line.

134p manmanthanhla0201 26-02-2024 2 1   Download

Luận án Tiến sĩ Chăn nuôi "Đa hình một số gen ứng viên và mối liên hệ với tính năng sản xuất của lợn Ỉ" trình bày các nội dung chính sau: Xác định được đặc điểm của lợn Ỉ thông qua kích thước một số chiều đo của lợn Ỉ cái và đực trong điều kiện chăn nuôi công nghiệp; Đánh giá được đa hình các gen ESR, PRLR, FSHB, RBP4, PIT1, MC4R, GHRH, FUT1, H-FABP, CAST, PIK3C3 và MYOG trên quần thể lợn Ỉ nuôi bảo tồn tại Công ty CP tập đoàn Dabaco, Việt Nam.

288p vilazada 02-02-2024 5 2   Download

SERPINC1 is a glycoprotein that regulates blood coagulation. SERPINC1 congenital or acquired deficiencies represent a significant risk factor for thromboembolic disease. SERPINC1 acquired defects are observed in very few cases and can occur in many clinical conditions such as treatment with l-asparaginase or oral contraceptive (particularly estrogen derivatives), but these conditions are not routinely investigated.

3p vitiki 30-01-2024 2 2   Download

Part 1 book "Hormones" includes content: Adrenal corticoids, hormones of the adrenal medulla, androgens, estrogens and progestins, hormones of pregnancy, parturition and lactation, hormones related to the kidney and cardiovascular system, the pineal gland, growth factors.

182p muasambanhan04 11-01-2024 2 1   Download

Bài viết báo cáo hai ca lâm sàng hiếm gặp ung thư nội mạc tử cung sau dùng tamoxifen được chẩn đoán và điều trị tại viện K. Qua đó nhìn lại y văn về tỷ lệ mắc, các yếu tố nguy cơ tiềm ẩn phát triển và tiên lượng bệnh ung thư nội mạc ở phụ nữ sử dụng tamoxifen để điều trị ung thư vú.

5p viplato 02-01-2024 4 2   Download

P-glycoprotein (P-gp), a member of the ATP Binding Cassette B1 subfamily (ABCB1), confers resistance to clinically relevant anticancer drugs and targeted chemotherapeutics. However, paradoxically P-glycoprotein overexpressing drug resistant cells are “collaterally sensitive” to non-toxic drugs that stimulate its ATPase activity.

14p vileonardodavinci 23-12-2023 4 2   Download

Estrogen receptor-positive and progesterone receptor-negative (ER+/PR-) breast cancer comprise a special type. More than 10% breast cancer patients belonged to ER+/PR-. In this study, we identified the clinical and genetic characteristics of ER+/PR- breast cancer patients in China. Distinct PR statuses indicated different biological processes of ER+breast cancer and survival outcomes. Future treatment strategies may need to be tailored for ER+/PR- patients.

11p vileonardodavinci 23-12-2023 5 2   Download

Public health systems in both industrialized and undeveloped countries continue to struggle with the worldwide problem of breast cancer. In sub-Saharan African countries, notably Ethiopia, it is the form of cancer that strikes women the most commonly. Despite the extreme difficulties, the causes of mortality in Ethiopia have not yet been identified. In addition, little study has been done in this area.

13p vileonardodavinci 23-12-2023 3 2   Download

This study aimed to assess the potential of pure β-glucosidase to hydrolyze glucoside phytoestrogens from soy germ to increase aglycones content. The optimal conditions for the hydrolysis of aglycones from soy germ evaporated extract included a β-glucosidase content of 4 units/g of defatted soy germ flour and an incubation time of 5.5 hours.

10p vialfrednobel 21-12-2023 5 2   Download

Lung adenocarcinoma (LUAD) is a common type of malignant tumor with poor prognosis and high mortality. In our previous studies, we found that estrogen is an important risk factor for LUAD, and different estrogen statuses can predict different prognoses.

16p vialfrednobel 23-12-2023 5 4   Download

Thyroid cancer (THCA) has become increasingly common in recent decades, and women are three to four times more likely to develop it than men. Evidence shows that estrogen has a significant impact on THCA proliferation and growth. Nevertheless, the effects of estrogen-related genes (ERGs) on THCA stages, immunological infiltration, and treatment susceptibility have not been well explored.

20p vialfrednobel 23-12-2023 3 2   Download

Bài viết trình bày xác định thời gian sống còn không bệnh tiến triển, thời gian sống còn toàn bộ của bệnh nhân carcinôm vú di căn thụ thể nội tiết dương tính, HER2 âm tính được điều trị thuốc ức chế CDK4/6 kết hợp nội tiết. Khảo sát một số yếu tố có thể ảnh hưởng đến sống còn không bệnh tiến triển, sống còn toàn bộ. Đánh giá một số độc tính của thuốc ức chế CDK4/6 kết hợp nội tiết.

16p vibranson 06-12-2023 11 4   Download

The objective of this study was to determine the expression of estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor (HER2), Ki67 and their correlation with other prognostic factors in invasive ductal carcinoma of breast.

5p vispacex 13-11-2023 5 2   Download

Part 3 book "Veterinary toxicology - Basic and clinical principles" includes content: Estrogenic toxicants; poisonous plants; mycotoxins; feed and water contaminants; analytical toxicology; prevention and treatment.

404p oursky08 02-11-2023 6 2   Download

Breast cancer patients of American Society of Clinical Oncology and the College of American Pathologists (ASCO/CAP) Group 2 were all HER2-negative according to the 2018 guideline, not HER2-positive as defined in the 2013 guideline.

13p vischultz 20-10-2023 6 1   Download

Rearranged during transfection (RET) tyrosine kinase signaling has been previously implicated in endocrine resistant breast cancer, however the mechanism by which this signaling cascade promotes resistance is currently not well described.

14p vischultz 20-10-2023 2 1   Download