intTypePromotion=1
zunia.vn Tuyển sinh 2024 dành cho Gen-Z zunia.vn zunia.vn
ADSENSE

Báo cáo khoa học: Catalytic activation of human glucokinase by substrate binding – residue contacts involved in the binding of D-glucose to the super-open form and conformational transitions

Chia sẻ: Nguyen Thang | Ngày: | Loại File: PDF | Số trang:15

45
lượt xem
4
download
 
  Download Vui lòng tải xuống để xem tài liệu đầy đủ

a-d-Glucose activates glucokinase (EC 2.7.1.1) on its binding to the active site by inducing a global hysteretic conformational change. Using intrinsic tryptophan fluorescence as a probe on the a-d-glucose induced conforma-tional changes in the pancreatic isoform 1 of human glucokinase, key resi-dues involved in the process were identified by site-directed mutagenesis.

Chủ đề:
Lưu

Nội dung Text: Báo cáo khoa học: Catalytic activation of human glucokinase by substrate binding – residue contacts involved in the binding of D-glucose to the super-open form and conformational transitions

ADSENSE

CÓ THỂ BẠN MUỐN DOWNLOAD

 

Đồng bộ tài khoản
5=>2