Báo cáo khoa hoc : Tying the knot The cystine signature and molecular-recognition processes of the vascular endothelial growth factor family of angiogenic cytokines
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The cystine-knot motif, made up of three intertwined disulfide bridges, is a unique feature of several toxins, cyclotides and growth factors, and occurs in a variety of species, including fungi, insects, molluscs and mammals. Growth factor molecules containing the cystine-knot motif serve as ligands for a diverse range of receptors and play an important role in extracellular signalling.
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